Extracellular Vesicles from Human Adipose-Derived Mesenchymal Stem Cells: A Review of Common Cargos.

Content Provider	Europe PMC
Author	Alonso-Alonso, Maria Luz García-Posadas, Laura Diebold, Yolanda
Abstract	In recent years, the interest in adipose tissue mesenchymal cell–derived extracellular vesicles (AT-MSC-EVs) has increasingly grown. Numerous articles support the potential of human AT-MSC-EVs as a new therapeutic option for treatment of diverse diseases in the musculoskeletal and cardiovascular systems, kidney, skin, and immune system, among others. This approach makes use of the molecules transported inside of EVs, which play an important role in cell communication and in transmission of macromolecules. However, to our knowledge, there is no database where essential information about AT-MSC-EVs cargo molecules is gathered for easy reference. The aim of this study is to describe the different molecules reported so far in AT-MSC- EVs, their main molecular functions, and biological processes in which they are involved. Recently, the presence of 591 proteins and 604 microRNAs (miRNAs) has been described in human AT-MSC-EVs. The main molecular function enabled by both proteins and miRNAs present in human AT-MSC-EVs is the binding function. Signal transduction and gene silencing are the biological processes in which a greater number of proteins and miRNAs from human AT-MSC-EVs are involved, respectively. In this review we highlight the therapeutics effects of AT-MSC-EVs related with their participation in relevant biological processes including inflammation, angiogenesis, cell proliferation, apoptosis and migration, among others.Graphical abstractSupplementary InformationThe online version contains supplementary material available at 10.1007/s12015-021-10155-5.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8942954&blobtype=pdf
ISSN	26293269
Journal	Stem Cell Reviews and Reports [Stem Cell Rev Rep]
Volume Number	18
DOI	10.1007/s12015-021-10155-5
PubMed Central reference number	PMC8942954
Issue Number	3
PubMed reference number	33904115
e-ISSN	26293277
Language	English
Publisher	Springer US
Publisher Date	2021-04-26
Publisher Place	New York
Access Restriction	Open
Rights License	Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2021
Subject Keyword	Extracellular vesicles Adipose-derived mesenchymal stem cells miRNA Proteomic Exosome
Content Type	Text
Resource Type	Article
Subject	Cell Biology Cancer Research