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Transient Response of Basal Ganglia Network in Healthy and Low-Dopamine State.
| Content Provider | Europe PMC |
|---|---|
| Author | Chakravarty, Kingshuk Roy, Sangheeta Sinha, Aniruddha Nambu, Atsushi Chiken, Satomi Hellgren Kotaleski, Jeanette Kumar, Arvind |
| Copyright Year | 2022 |
| Abstract | The basal ganglia (BG) are crucial for a variety of motor and cognitive functions. Changes induced by persistent low-dopamine (e.g., in Parkinson’s disease; PD) result in aberrant changes in steady-state population activity (β band oscillations) and the transient response of the BG. Typically, a brief cortical stimulation results in a triphasic response in the substantia nigra pars reticulata (SNr; an output of the BG). The properties of the triphasic responses are shaped by dopamine levels. While mechanisms underlying aberrant steady state activity are well studied, it is still unclear which BG interactions are crucial for the aberrant transient responses in the BG. Moreover, it is also unclear whether mechanisms underlying the aberrant changes in steady-state activity and transient response are the same. Here, we used numerical simulations of a network model of BG to identify the key factors that determine the shape of the transient responses. We show that an aberrant transient response of the SNr in the low-dopamine state involves changes in the direct pathway and the recurrent interactions within the globus pallidus externa (GPe) and between GPe and subthalamic nucleus (STN). However, the connections from D2-type spiny projection neurons (D2-SPN) to GPe are most crucial in shaping the transient response and by restoring them to their healthy level, we could restore the shape of transient response even in low-dopamine state. Finally, we show that the changes in BG that result in aberrant transient response are also sufficient to generate pathologic oscillatory activity in the steady state. |
| Page Count | 26 |
| Journal | eNeuro |
| Volume Number | 9 |
| PubMed Central reference number | PMC8938981 |
| Issue Number | 2 |
| PubMed reference number | 35140075 |
| e-ISSN | 23732822 |
| DOI | 10.1523/ENEURO.0376-21.2022 |
| Language | English |
| Publisher | Society for Neuroscience |
| Publisher Date | 2022-03-18 |
| Access Restriction | Open |
| Rights License | This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Copyright © 2022 Chakravarty et al. |
| Subject Keyword | basal ganglia direct pathway indirect pathway network model Parkinson’s disease transient response |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Neuroscience |
