Differences in single positive formal thought disorder symptoms between closely matched acute patients with schizophrenia and mania.

Content Provider	Europe PMC
Author	Kircher, Tilo Stein, Frederike Nagels, Arne
Abstract	Formal thought disorders (FTD) are a hallmark diagnostic feature of schizophrenia (SZ) and (bipolar) mania (MA). FTD can be separated into positive (pFTD) and negative dimensions. It is unclear whether there are differences in pFTD on a single symptom level between acutely ill patients with SZ and MA, which cannot be attributed to cognitive impairment. We compared single pFTD symptoms in two groups of acutely ill patients with ICD-10 bipolar mania and schizophrenia, closely matched for age, sex, pFTD TALD score, verbal IQ and neuropsychological test performance (executive function, verbal fluency, attention, and working memory). SZ patients had higher severity of the TALD symptoms “perseverations” and “poverty of content of speech” than those with MA (Mann–Whitney U, significant, Bonferroni corrected). Speech in acute SZ patients differs from MA in that it conveys little information and adheres to previously mentioned ideas and topics. Matching for confounding variables, such as IQ and cognition, is important when comparing patients with different diagnoses.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8938354&blobtype=pdf
ISSN	09401334
Journal	European Archives of Psychiatry and Clinical Neuroscience [Eur Arch Psychiatry Clin Neurosci]
Volume Number	272
DOI	10.1007/s00406-021-01263-x
PubMed Central reference number	PMC8938354
Issue Number	3
PubMed reference number	33961098
e-ISSN	14338491
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2021-05-07
Publisher Place	Berlin/Heidelberg
Access Restriction	Open
Rights License	Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2021
Subject Keyword	Poverty of content of speech Perseveration TALD Formal thought disorder Schizophrenia Mania
Content Type	Text
Resource Type	Article
Subject	Biological Psychiatry Pharmacology (medical) Psychiatry and Mental Health