Toxic epidermal necrolysis induced by ritodrine in pregnancy: A case report.

Content Provider	Europe PMC
Author	Liu, Wen-Yu Zhang, Jia-Rong Xu, Xian-Ming Ye, Tian-Yi
Copyright Year	2022
Abstract	BACKGROUNDPreterm birth accounts for about 12% of all pregnancies worldwide and is the leading cause of neonatal morbidity and mortality. In order to avoid premature birth and prolong gestational age, tocolytics are the first and the best choice. Ritodrine is the most commonly used tocolytic medication. However, side effects such as pulmonary edema, hypokalemia, and hyperglycemia are known. Here we report a rare but serious side effect–toxic epidermal necrolysis (TEN)–caused by ritodrine.CASE SUMMARYA woman (31 years, gravida 4, para 2) was hospitalized because of premature contractions at 27 + 6 wk of gestation. A skin rash with pruritus appeared at 32 + 3 wk of gestation after administration of ritodrine, indomethacin, and dexamethasone, and it spread throughout the whole body in 3 d, particularly the four limbs. After 11 d’ treatment, she was diagnosed with TEN. An emergency cesarean section was performed immediately to deliver the baby and intensive symptomatic treatment was promptly commenced after delivery. She recovered from the severe condition without any sequelae except for slight pigmentation after symptomatic treatment.CONCLUSIONWhen a skin rash appears during the administration of ritodrine, we are supposed to consider the risk of TEN.
Volume Number	10
PubMed Central reference number	PMC8855204
Issue Number	4
PubMed reference number	35211573
Journal	World Journal of Clinical Cases
e-ISSN	23078960
DOI	10.12998/wjcc.v10.i4.1381
Language	English
Publisher	Baishideng Publishing Group Inc
Publisher Date	2022-02-01
Access Restriction	Open
Rights License	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Subject Keyword	Preterm birth Ritodrine Side effect Tocolytics Toxic epidermal necrolysis Case report
Content Type	Text
Resource Type	Article
Subject	Medicine