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A human pluripotent stem cell-based model of SARS-CoV-2 infection reveals an ACE2-independent inflammatory activation of vascular endothelial cells through TLR4.
| Content Provider | Europe PMC |
|---|---|
| Author | Ma, Zhangjing Li, Xisheng Fan, Rebecca L.Y. Yang, Kevin Y. Ng, Calvin S.H. Lau, Rainbow W.H. Wong, Randolph H.L. Ng, Kevin K. Wang, Chi Chiu Ye, Peng Fu, Zelong Chin, Alex W.H. Lai, M.Y. Alison Huang, Yu Tian, Xiao Yu Poon, Leo L.M. Lui, Kathy O. |
| Copyright Year | 2022 |
| Journal | Stem Cell Reports |
| Volume Number | 17 |
| PubMed Central reference number | PMC8851885 |
| Issue Number | 3 |
| PubMed reference number | 35180397 |
| e-ISSN | 22136711 |
| DOI | 10.1016/j.stemcr.2022.01.015 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2022-02-17 |
| Access Restriction | Open |
| Rights License | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). © 2022 The Author(s) |
| Subject Keyword | SARS-CoV-2 COVID-19 scRNA-seq endothelial inflammation monocyte adhesion ACE2 TLR4 p38 MAPK NF-κB IL-1β |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry Cell Biology Developmental Biology Genetics |