NDLI: Long-chain fatty acyl-CoA synthetase 1 promotes prostate cancer progression by elevation of lipogenesis and fatty acid beta-oxidation.

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Long-chain fatty acyl-CoA synthetase 1 promotes prostate cancer progression by elevation of lipogenesis and fatty acid beta-oxidation.

Content Provider	Europe PMC
Author	Ma, Yongjie Zha, Junyi Yang, XiangKun Li, Qianjin Zhang, Qingfu Yin, Amelia Beharry, Zanna Huang, Hanwen Huang, Jiaoti Bartlett, Michael Ye, Kaixiong Yin, Hang Cai, Houjian
Abstract	Fatty acid metabolism is essential for the biogenesis of cellular components and ATP production to sustain proliferation of cancer cells. Long chain fatty acyl-CoA synthetases (ACSLs), a group of rate-limiting enzymes in fatty acid metabolism, catalyze the bioconversion of exogenous or de novo synthesized fatty acids to their corresponding fatty acyl-CoAs. In this study, systematical analysis of ACSLs levels and the amount of fatty acyl-CoAs illustrated that ACSL1 were significantly associated with the levels of a broad spectrum of fatty acyl-CoAs, and were elevated in human prostate tumors. ACSL1 increased the biosynthesis of fatty acyl-CoAs including C16:0-, C18:0-, C18:1- and C18:2-CoA, triglycerides and lipid accumulation in cancer cells. Mechanistically, ACSL1 modulated mitochondrial respiration, β-oxidation and ATP production through regulation of CPT1 activity. Knockdown of ACSL1 inhibited the cell cycle, and suppressed the proliferation and migration of prostate cancer cells in vitro, and growth of prostate xenograft tumors in vivo. Our study implicates ACSL1 as playing an important role in prostate tumor progression, and provides a therapeutic strategy of targeting fatty acid metabolism for the treatment of prostate cancer.
ISSN	09509232
Volume Number	40
PubMed Central reference number	PMC8842993
Issue Number	10
PubMed reference number	33564069
Journal	Oncogene
e-ISSN	14765594
DOI	10.1038/s41388-021-01667-y
Language	English
Publisher Date	2021-02-09
Access Restriction	Open
Rights License	Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
Subject Keyword	ACSL1 fatty acid metabolism fatty acyl-CoAs prostate cancer
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Cancer Research

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