NDLI: Sex Differences in RANTES (CCL5) in Patients With Intermediate Age-Related Macular Degeneration (AMD) and Controls With no AMD.

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Sex Differences in RANTES (CCL5) in Patients With Intermediate Age-Related Macular Degeneration (AMD) and Controls With no AMD.

Content Provider	Europe PMC
Author	Fonteh, Cheryl N. Palestine, Alan G. Wagner, Brandie D. Patnaik, Jennifer L. Mathias, Marc T. Mandava, Naresh Baldermann, Rebecca Lynch, Anne M.
Copyright Year	2022
Abstract	PurposeTo determine if there are sex differences in levels of regulated upon activation, normal T cell expressed and secreted (RANTES) in patients with intermediate age-related macular degeneration (iAMD) and in controls with no AMD.MethodsPatients with iAMD and controls defined by multi-modal imaging were recruited into a Colorado AMD registry. Plasma levels of the chemokine RANTES were measured using a multiplex assay. A nonparametric (rank-based) regression model was fit to RANTES with a sex by AMD category interaction.ResultsThe plasma level of RANTES was significantly higher in the control group in comparison with the iAMD group. When moderated by sex, RANTES was significantly lower (P = 0.005) in males (median, 4525.6 pg/mL; interquartile range, 2589–7861 pg/mL) compared with females (median, 6686 pg/mL; interquartile range, 3485–12488 pg/mL) within the iAMD cohort. No significant difference was found in levels of RANTES between males and females in the control group.ConclusionsWe found that levels of RANTES were moderated by sex in cases with iAMD with lower levels in males compared with females. The findings illustrate the importance of including sex as a biological variable in AMD research. There is a need for further studies of RANTES, stratified by sex, in the advanced phenotypes of AMD.Translational RelevanceThe biomarker RANTES identified in the plasma of patients with iAMD reflects systemic alterations when stratified by sex.
Page Count	9
Journal	Translational Vision Science & Technology
Volume Number	11
PubMed Central reference number	PMC8842629
Issue Number	2
PubMed reference number	35133404
e-ISSN	21642591
DOI	10.1167/tvst.11.2.12
Language	English
Publisher	The Association for Research in Vision and Ophthalmology
Publisher Date	2022-02-01
Access Restriction	Open
Rights License	This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. Copyright 2022 The Authors
Subject Keyword	age-related macular degeneration sex differences RANTES
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering Ophthalmology

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