NDLI: Recent applications of cell-penetrating peptide guidance of nanosystems in breast and prostate cancer.

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Recent applications of cell-penetrating peptide guidance of nanosystems in breast and prostate cancer.

Content Provider	Europe PMC
Author	Longoria-García, Samuel Sánchez-Domínguez, Celia Nohemi Gallardo-Blanco, Hugo Leonid
Copyright Year	2022
Abstract	Cell-penetrating peptides (CPPs) are small peptides from natural sources or designed from other protein sequences that can penetrate cell membranes. This property has been used in biomedicine to add them to biomolecules to improve their capacity for cell internalization and as a guidance tool for specific cell types. CPPs have been shown to enhance cellular uptake in vitro and in vivo, improving the efficacy of anticancer drugs such as doxorubicin and paclitaxel, while also limiting their cytotoxic effects on healthy cells and tissues. The current study reviews the internalization and major therapeutic results achieved from the functionalization of nanosystems with CPPs for guidance into breast and prostate cancer cells in vitro and in vivo. In addition, the practical results obtained are specifically discussed for use as a starting point for scientists looking to begin research in this field.
ISSN	17921074
Journal	Oncology Letters
Volume Number	23
PubMed Central reference number	PMC8822396
Issue Number	3
PubMed reference number	35154434
e-ISSN	17921082
DOI	10.3892/ol.2022.13223
Language	English
Publisher	D.A. Spandidos
Publisher Date	2022-02-01
Access Restriction	Open
Rights License	This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Copyright: © Longoria-García et al.
Subject Keyword	nanosystems nanoparticles cell-penetrating peptides breast cancer prostate cancer
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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