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Heart Failure with Preserved Ejection Fraction: a Pharmacotherapeutic Update.
| Content Provider | Europe PMC |
|---|---|
| Author | Vaz-Salvador, Pedro Adão, Rui Vasconcelos, Inês Leite-Moreira, Adelino F. Brás-Silva, Carmen |
| Abstract | While guidelines for management of heart failure with reduced ejection fraction (HFrEF) are consensual and have led to improved survival, treatment options for heart failure with preserved ejection fraction (HFpEF) remain limited and aim primarily for symptom relief and improvement of quality of life. Due to the shortage of therapeutic options, several drugs have been investigated in multiple clinical trials. The majority of these trials have reported disappointing results and have suggested that HFpEF might not be as simply described by ejection fraction as previously though. In fact, HFpEF is a complex clinical syndrome with various comorbidities and overlapping distinct phenotypes that could benefit from personalized therapeutic approaches. This review summarizes the results from the most recent phase III clinical trials for HFpEF and the most promising drugs arising from phase II trials as well as the various challenges that are currently holding back the development of new pharmacotherapeutic options for these patients. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8801287&blobtype=pdf |
| ISSN | 09203206 |
| Journal | Cardiovascular Drugs and Therapy [Cardiovasc Drugs Ther] |
| Volume Number | 37 |
| DOI | 10.1007/s10557-021-07306-8 |
| PubMed Central reference number | PMC8801287 |
| Issue Number | 4 |
| PubMed reference number | 35098432 |
| e-ISSN | 15737241 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2022-01-31 |
| Publisher Place | New York |
| Access Restriction | Open |
| Rights License | This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 |
| Subject Keyword | Heart failure Preserved ejection fraction Pharmacotherapy Clinical trials |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) Cardiology and Cardiovascular Medicine |
