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Diagnostic accuracy of endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA) for mediastinal lymph node staging of lung cancer.
| Content Provider | Europe PMC |
|---|---|
| Author | Torre, Massimo Reda, Marco Musso, Valeria Danuzzo, Federica Mohamed, Shehab Conforti, Serena |
| Copyright Year | 2021 |
| Abstract | Lung cancer is one of the leading causes of cancer-related mortality around the world. A prompt diagnosis and accurate staging are of the essence in order to establish the appropriate treatment plan. Mediastinal lymph nodes involvement is the most important parameter to define the therapeutic path, and particularly to decide whether a patient can be offered a potentially curative surgery. Endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA), together with oesophageal ultrasound (EUS), has a pivotal role in the diagnosis and staging of lung cancer. These procedures have excellent diagnostic performances, can be performed without requiring general anaesthesia, and are far less invasive than mediastinoscopy and video-assisted thoracic surgery (VATS). Moreover, EBUS-TBNA allows to biopsy intrapulmonary lymph nodes. Different studies have been investigated the diagnostic accuracy of EBUS-TBNA for the diagnosis and staging of lung cancer, with always good but heterogeneous results. In some studies, EBUS-TBNA has shown to yield adequate samples for molecular testing and immunocytochemistry too. Rapid on site cytologic evaluation (ROSE) can be used to assess the adequacy of samples during the endoscopic procedure. The aim of this review article is to describe the current evidence on the diagnostic accuracy of EBUS-TBNA for the diagnosis of lung cancer. We also reported our centre’s experience and the results of 456 EBUS-TBNA performed between April 2016 and March 2020. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8794299&blobtype=pdf |
| Journal | Mediastinum |
| Volume Number | 5 |
| DOI | 10.21037/med-21-2 |
| PubMed Central reference number | PMC8794299 |
| PubMed reference number | 35118321 |
| e-ISSN | 25226711 |
| Language | English |
| Publisher | AME Publishing Company |
| Publisher Date | 2021-06-25 |
| Access Restriction | Open |
| Rights License | Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/. 2021 Mediastinum. All rights reserved. |
| Subject Keyword | Endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA) non-small cell lung cancer (NSCLC) endoscopy staging |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Cardiology and Cardiovascular Medicine Endocrinology, Diabetes and Metabolism Pulmonary and Respiratory Medicine Medicine Oncology |
