The Associations Between Serum Concentrations of Irisin and Glucose-dependent Insulinotropic Polypeptide with Body Mass Index Among Women with and Without Polycystic Ovary Syndrome.

Content Provider	Europe PMC
Author	Behboudi-Gandevani, Samira Hedayati, Mehdi Mansournia, Mohammad Ali Nazemipour, Maryam Rahmati, Maryam Ramezani Tehrani, Fahimeh
Copyright Year	2021
Abstract	BackgroundThe actions of adipocytokines may be a connective factor between obesity and polycystic ovary syndrome (PCOS). It is suggested that irisin, as recently described cytokine secreted by skeletal muscles and glucose-dependent insulinotropic polypeptide (GIP) as an incretin hormone that induces cytokine expression, may play key roles in favoring obesity in these women.ObjectivesWe aimed to evaluate the association between body mass index (BMI) and serum concentrations of irisin/GIP in women with and without PCOS in the linear and non-linear models.MethodsThis cross-sectional study was conducted among 159 PCOS and 82 healthy eumenorrheic non-hirsute women aged 20 - 50 years. The fractional-polynomial model was used to develop a model of continuous risk factors, which evaluates non-linear associations between irisin/GIP and BMI among women with and without PCOS.ResultsWomen with PCOS were significantly younger (28.2 ± 5.8 vs. 33.0 ± 7.8 years, P < 0.001) and had a greater BMI (26.6 ± 5.2 vs. 25.2 ± 4.8 kg/m2, P = 0.04) than the healthy counterparts. There were no significant linear and non-linear associations between serum concentration of irisin/GIP and BMI in both groups. The analysis of pair-wise age and BMI matching of women with PCOS and controls confirmed these findings.ConclusionsThis study showed that irisin and GIP have no association with BMI in women with or without PCOS. This finding could help to better understand the underlying pathophysiological status of PCOS, insulin resistance, and obesity-related disorders. Further large cohort studies are needed to confirm these findings.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8761486&blobtype=pdf
ISSN	1726913X
Journal	International Journal of Endocrinology and Metabolism [Int J Endocrinol Metab]
Volume Number	19
DOI	10.5812/ijem.111914
PubMed Central reference number	PMC8761486
Issue Number	4
PubMed reference number	35043052
e-ISSN	17269148
Language	English
Publisher	Kowsar
Publisher Date	2021-05-31
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited. Copyright © 2021, International Journal of Endocrinology and Metabolism
Subject Keyword	Adipocytokine Body Mass Index Insulin Resistance Polycystic Ovary Syndrome
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism