NDLI: Microglial activation induced by LPS mediates excitation of neurons in the hypothalamic paraventricular nucleus projecting to the rostral ventrolateral medulla.

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Microglial activation induced by LPS mediates excitation of neurons in the hypothalamic paraventricular nucleus projecting to the rostral ventrolateral medulla.

Content Provider	Europe PMC
Author	Han, Tae Hee Lee, Heow Won Kang, Eun A Song, Min Seok Lee, So Yeong Ryu, Pan Dong
Copyright Year	2021
Abstract	Microglia are known to be activated in the hypothalamic para-ventricular nucleus (PVN) of rats with cardiovascular diseases. However, the exact role of microglial activation in the plasticity of presympathetic PVN neurons associated with the modulation of sympathetic outflow remains poorly investigated. In this study, we analyzed the direct link between microglial activation and spontaneous firing rate along with the underlying synaptic mechanisms in PVN neurons projecting to the rostral ventrolateral medulla (RVLM). Systemic injection of LPS induced microglial activation in the PVN, increased the frequency of spontaneous firing activity of PVN-RVLM neurons, reduced GABAergic inputs into these neurons, and increased plasma NE levels and heart rate. Systemic minocycline injection blocked all the observed LPS-induced effects. Our results indicate that LPS increases the firing rate and decreases GABAergic transmission in PVN-RVLM neurons associated with sympathetic outflow and the alteration is largely attributed to the activation of microglia. Our findings provide some insights into the role of microglial activation in regulating the activity of PVN-RVLM neurons associated with modulation of sympathetic outflow in cardiovascular diseases.
ISSN	19766696
Journal	BMB Reports
Volume Number	54
PubMed Central reference number	PMC8728541
Issue Number	12
PubMed reference number	34814975
e-ISSN	1976670X
DOI	10.5483/BMBRep.2021.54.12.105
Language	English
Publisher	Korean Society for Biochemistry and Molecular Biology
Publisher Date	2021-12-01
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2021 by the The Korean Society for Biochemistry and Molecular Biology
Subject Keyword	GABAergic transmission Microglial activation Neuronal activity PVN-RVLM Sympathetic outflow
Content Type	Text
Resource Type	Article
Subject	Medicine Molecular Biology Biochemistry

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