Metabolic syndrome, intracranial arterial stenosis and cerebral small vessel disease in community-dwelling populations.

Content Provider	Europe PMC
Author	Shu, Mei-Jun Zhai, Fei-Fei Zhang, Ding-Ding Han, Fei Zhou, Lixin Ni, Jun Yao, Ming Zhang, Shu-Yang Cui, Li-Ying Jin, Zheng-Yu Zhu, Hui-Juan Zhu, Yi-Cheng
Copyright Year	2021
Abstract	Background and purposeThis study aimed to investigate the association of metabolic syndrome (MetS) with both intracranial atherosclerotic stenosis (ICAS) and imaging markers of cerebral small vessel disease (CSVD) in a community-based sample.MethodsThis study included 943 participants (aged 55.6±9.2 years, 36.1% male) from the community-based Shunyi cohort study. MetS was defined according to the joint interim criteria and quantified by the MetS severity Z-score. ICAS was evaluated by brain magnetic resonance angiography. The MRI markers of CSVD, including white matter hyperintensities (WMHs), lacunes, cerebral microbleeds (CMBs) and enlarged perivascular spaces (EPVS), were assessed. Multiple regression models were used to investigate the association of MetS severity Z-score with ICAS and these CSVD markers.ResultsWe found that risk of ICAS (OR=1.75, 95% CI 1.39 to 2.21, p<0.001) increased consistently with MetS severity. MetS severity was significantly associated with higher risks of WMH volume (β=0.11, 95% CI 0.01 to 0.20, p=0.02) and lacunes (OR=1.28, 95% CI 1.03 to 1.59, p=0.03) but not the presence of CMBs (OR=0.93, 95% CI 0.74 to 1.16, p=0.51) and PVS severity (EPVS in basal ganglia: OR=0.96, 95% CI 0.84 to 1.09, p=0.51 and EPVS in white matter: OR=1.09, 95% CI 0.96 to 1.23, p=0.21).ConclusionsOur findings suggest that WMH and lacunes share risk factors with atherosclerosis of the cerebral artery, whereas the impact of glucose and lipid metabolic disorder to CMB or EPVS might be weak.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8717787&blobtype=pdf
Journal	Stroke and Vascular Neurology [Stroke Vasc Neurol]
Volume Number	6
DOI	10.1136/svn-2020-000813
PubMed Central reference number	PMC8717787
Issue Number	4
PubMed reference number	33903177
e-ISSN	20598696
Language	English
Publisher	BMJ Publishing Group
Publisher Date	2021-04-26
Publisher Place	BMA House, Tavistock Square, London, WC1H 9JR
Access Restriction	Open
Rights License	This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Subject Keyword	atherosclerosis brain MRI stroke artery
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine Neurology (clinical)