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Sustained low efficiency dialysis is non-inferior to continuous renal replacement therapy in critically ill patients with acute kidney injury: A comparative meta-analysis.
| Content Provider | Europe PMC |
|---|---|
| Author | Dalbhi, Sultan Al Alorf, Riyadh Alotaibi, Mohammad Altheaby, Abdulrahman Alghamdi, Yasser Ghazal, Hadeel Almuzaini, Hussam Negm, Helmy |
| Editor | Saranathan., Maya |
| Copyright Year | 2021 |
| Abstract | AbstractBackground:Critically ill adults with acute kidney injury (AKI) experience considerable morbidity and mortality. This systematic review aimed to compare the effectiveness of continuous renal replacement therapy (CCRT) versus sustained low efficiency dialysis (SLED) for individuals with AKI.Methods:We carried out a systematic search of existing databases according to standard methods and random effects models were used to generate the overall estimate. Heterogeneity coefficient was also calculated for each outcome measure.Results:Eleven studies having 1160 patients with AKI were included in the analyses. Meta-analysis results indicated that there was no statistically significant difference between SLED versus continuous renal replacement therapy (CRRT) in our primary outcomes, like mortality rate (rate ratio [RR] 0.67, 95% confidence interval [CI] 0.44–1.00; P = .05), renal recovery (RR 1.08, 95% CI 0.83–1.42; P = .56), and dialysis dependence (RR = 1.03, 95% CI 0.69–1.53; P = .89). Also, no statistically significant difference was observed for between SLED versus CRRT in the secondary outcomes: that is, length of intensive care unit stay (mean difference –0.16, 95% CI –0.56–0.22; P = .41) and fluid removal rate (mean difference –0.24, 95% CI –0.72–0.24; P = .32). The summary mean difference indicated that there was a significant difference in the serum phosphate clearance among patients treated with SLED and CRRT (mean difference –1.17, 95% CI –1.90 to –0.44, P = .002).Conclusions:The analysis indicate that there was no major advantage of using continuous renal replacement compared with sustained low efficiency dialysis in hemodynamically unstable AKI patients. Both modalities are equally safe and effective in treating AKI among critically ill patients. |
| ISSN | 00257974 |
| Journal | Medicine |
| Volume Number | 100 |
| PubMed Central reference number | PMC8702221 |
| Issue Number | 51 |
| PubMed reference number | 34941056 |
| e-ISSN | 15365964 |
| DOI | 10.1097/md.0000000000028118 |
| Language | English |
| Publisher | Lippincott Williams & Wilkins |
| Publisher Date | 2021-12-01 |
| Publisher Place | Hagerstown, MD |
| Access Restriction | Open |
| Rights License | This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. |
| Subject Keyword | acute kidney injury continuous renal replacement therapy hemodynamic instability intensive care meta-analysis sustained low efficiency dialysis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
