NDLI: Toxigenic <i>Clostridium difficile</i>-mediated diarrhoea in hematopoietic stem cell transplantation in-patients: rapid diagnosis and efficient treatment.

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Toxigenic Clostridium difficile-mediated diarrhoea in hematopoietic stem cell transplantation in-patients: rapid diagnosis and efficient treatment.

Content Provider	Europe PMC
Author	Khodaparast, Sepideh Mohabati Mobarez, Ashraf Khoramabadi, Nima Vasei, Mohammad Saberifiroozi, Mehdi
Copyright Year	2021
Abstract	Allogenic hematopoietic stem cell transplant (HSCT) recipients are susceptible to any kind of infectious agents including Clostridium difficile. We studied 86 allogenic-HSCT patients who faced diarrhoea while receiving antibiotics. DNA from stool samples were explored for the presence of C. difficile toxin genes (tcdA; tcdB) by multiplex real-time PCR. Results showed nine toxigenic C. difficile amongst which seven were positive for both toxins and two were positive for tcdB. Six of toxigenic C. difficile organisms harbouring both toxin genes were also isolated by toxigenic culture. Clostridium difficile infection was controlled successfully with oral Metronidazole and Vancomycin in the confirmed infected patients.
Page Count	3
ISSN	09502688
Journal	Epidemiology and Infection
Volume Number	149
PubMed Central reference number	PMC8697310
PubMed reference number	34372951
e-ISSN	14694409
DOI	10.1017/S095026882100162X
Language	English
Publisher	Cambridge University Press
Publisher Date	2021-08-10
Publisher Place	Cambridge, UK
Access Restriction	Open
Rights License	This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited. © The Author(s) 2021
Subject Keyword	Clostridium difficile hematopoietic stem cell transplant real-time PCR
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Epidemiology

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