Early intervention of acute liver injury related to venlafaxine: A case report.

Content Provider	Europe PMC
Author	Fang, Lin Wang, Shushan Cao, Leiming Yao, Kun
Editor	Saranathan., Maya
Copyright Year	2021
Abstract	AbstractRationale:Drug-induced liver injury (DILI) is the leading cause of acute liver injury (ALI), market withdrawal of a drug, and rejection of applications for marketing licenses. The incidence of DILI is very low, with a value between 1 and 19 per 100,000 patient years. All antidepressants may induce DILI even at low therapeutic doses. In this report, we present a case of ALI after venlafaxine administration.Patient concerns:A 27-year-old Chinese Han woman was admitted for depression. Several serum liver function indices in this patient were abnormal after antidepressant treatment. The Roussel Uclaf Causality Assessment Method (RUCAM) causality assessment score was 8, and the R value was 31.18.Diagnoses:The patient was diagnosed with hepatocellular ALI, which was derived from venlafaxine-related adverse events.Interventions:First, all medications were stopped to block the progression of DILI. Then, a hepatoprotective strategy and proper psychological treatment were performed to recover the impaired hepatic function.Outcomes:Liver function was fully recovered as indicated by liver function indices and ultrasound imaging.Lessons:The possibility of DILI should not be overlooked during the long-term use of antipsychotic drugs. In response, regular liver function monitoring should be performed in a timely manner to avoid missing diagnoses and delayed treatment. Furthermore, the necessary medical treatment needs to be conducted after the occurrence of ALI.
ISSN	00257974
Journal	Medicine
Volume Number	100
PubMed Central reference number	PMC8663904
Issue Number	49
PubMed reference number	34889278
e-ISSN	15365964
DOI	10.1097/md.0000000000028140
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2021-12-01
Publisher Place	Hagerstown, MD
Access Restriction	Open
Rights License	This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
Subject Keyword	acute liver injury drug-induced liver injure causality assessment venlafaxine
Content Type	Text
Resource Type	Article
Subject	Medicine