Comparison of thyroid-stimulating hormone levels in adolescents with schizophrenia, bipolar disorder, unipolar depression, conduct disorders, and hyperkinetic disorders.

Content Provider	Europe PMC
Author	Makarow-Gronert, Agnieszka Margulska, Aleksandra Strzelecki, Dominik Krajewska, Katarzyna Gmitrowicz, Agnieszka Gawlik-Kotelnicka, Oliwia
Editor	Saranathan., Maya
Copyright Year	2021
Abstract	AbstractThe aim of this study was to retrospectively compare values of thyroid-stimulating hormone (TSH) in adolescent patients diagnosed with schizophrenia, bipolar disorder, unipolar depression (UNI-DEP), conduct disorders (CD), and hyperkinetic disorders.The research involved 1122 patients (718 women, 64%); aged 12 to 18 hospitalized in the Department of Adolescent Psychiatry, Medical University of Lodz. We analyzed TSH levels in the whole study population and compared it between the above-mentioned subgroups of diagnoses.Mean serum TSH concentration in the studied population (n = 1122) was 2.06 μIU/mL. The values of percentiles were as follows: 2.5th – 0.53 μIU/mL, 10th – 0.89 μIU/mL, 25th – 1.31 μIU/mL, 50th – 1.9 μIU/mL, 75th – 2.6 μIU/mL, 90th – 3.43 μIU/mL, 97.5th – 4.72 μIU/mL. TSH values were negatively correlated with patients’ age (P = .00001). Patients with bipolar depression had higher TSH levels than patients with CD (P = .002). Also, when male and female groups were examined separately we found that female patients with UNI-DEP and bipolar disorder had higher TSH levels than female patients with CD (P = .001; P = .001).Our results confirm that there may be a higher prevalence of thyroid dysfunctions in bipolar and UNI-DEP subgroups among adolescents and that it is worthy to consider some kind of interventions regarding thyroid function in depressed individuals.
ISSN	00257974
Journal	Medicine
Volume Number	100
PubMed Central reference number	PMC8663859
Issue Number	49
PubMed reference number	34889284
e-ISSN	15365964
DOI	10.1097/md.0000000000028160
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2021-12-01
Publisher Place	Hagerstown, MD
Access Restriction	Open
Rights License	This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
Subject Keyword	adolescents bipolar disorder conduct disorders depression hyperkinetic disorders schizophrenia thyroid-stimulating hormone
Content Type	Text
Resource Type	Article
Subject	Medicine