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Immunogenicity after two doses of inactivated virus vaccine in healthcare workers with and without previous COVID-19 infection: Prospective observational study.
| Content Provider | Europe PMC |
|---|---|
| Author | Yalçın, Tuğba Y. Topçu, Deniz İ. Doğan, Özlem Aydın, Saliha Sarı, Nuran Erol, Çiğdem Kuloğlu, Zeynep E. Azap, Özlem K. Can, Füsun Arslan, Hande |
| Abstract | Vaccines have been seen as the most important solution for ending the coronavirus disease 2019 (COVID‐19) pandemic. The aim of this study is to evaluate the antibody levels after inactivated virus vaccination. We included 148 healthcare workers (74 with prior COVID‐19 infection and 74 with not). They received two doses of inactivated virus vaccine (CoronaVac). Serum samples were prospectively collected three times (Days 0, 28, 56). We measured SARS‐CoV‐2 IgGsp antibodies quantitatively and neutralizing antibodies. After the first dose, antibody responses did not develop in 64.8% of the participants without prior COVID‐19 infection. All participants had developed antibody responses after the second dose. We observed that IgGsp antibody titers elicited by a single vaccine dose in participants with prior COVID‐19 infection were higher than after two doses of vaccine in participants without prior infection (geometric mean titer: 898 and 607 AU/ml). IgGsp antibodies, participants with prior COVID‐19 infection had higher antibody levels as geometric mean titers at all time points (p < 0.001). We also found a positive correlation between IgGsp antibody titers and neutralizing capacity (r s = 0.697, p < 0.001). Although people without prior COVID‐19 infection should complete their vaccination protocol, the adequacy of a single dose of vaccine is still in question for individuals with prior COVID‐19. New methods are needed to measure the duration of protection of vaccines and their effectiveness against variants as the world is vaccinated. We believe quantitative IgGsp values may reflect the neutralization capacity of some vaccines. |
| Page Count | 8 |
| ISSN | 01466615 |
| Journal | Journal of Medical Virology |
| Volume Number | 94 |
| PubMed Central reference number | PMC8661640 |
| Issue Number | 1 |
| PubMed reference number | 34468990 |
| e-ISSN | 10969071 |
| DOI | 10.1002/jmv.27316 |
| Language | English |
| Publisher | John Wiley and Sons Inc. |
| Publisher Date | 2021-09-10 |
| Publisher Place | Hoboken |
| Access Restriction | Open |
| Rights License | This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency. © 2021 Wiley Periodicals LLC |
| Subject Keyword | coronaVac immunogenicity inactivated virus vaccine neutralizing antibody SARS‐CoV‐2 antibody |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Virology |
