Tumor-Educated Platelets: A Review of Current and Potential Applications in Solid Tumors.

Content Provider	Europe PMC
Author	Varkey, Joyce Nicolaides, Theodore
Editor	Muacevic, Alexander Adler, John R
Copyright Year	2021
Abstract	In this current era of precision medicine, liquid biopsy poses a unique opportunity for an easily accessible, comprehensive molecular profile that would allow for the identification of therapeutic targets and sequential monitoring. Solid tumors are definitively diagnosed by analyzing primary tumor tissue, but surgical sampling is not always sufficient to generate a comprehensive genetic fingerprint at the time of diagnosis, or an appropriate means for continued monitoring. Platelets are known to have a dynamic, bidirectional relationship with tumors, acting beyond their role of hemostasis. Tumor-educated platelets (TEP) are modified by the tumor in multiple ways and act as a carrier and protector of metastasis. Data so far have shown that the mRNA in TEP can be harnessed for cancer diagnostics, with many potential applications.
Journal	Cureus
Volume Number	13
DOI	10.7759/cureus.19189
PubMed Central reference number	PMC8635758
Issue Number	11
PubMed reference number	34873529
e-ISSN	21688184
Language	English
Publisher	Cureus
Publisher Date	2021-11-01
Publisher Place	Palo Alto (CA)
Access Restriction	Open
Subject Keyword	liquid biopsy solid tumor tumor-educated platelet lung cancer oncology
Content Type	Text
Resource Type	Article
Subject	Medicine