High-intensity interval training and pulmonary hemodynamics in COPD with hypoxemia.

Content Provider	Europe PMC
Author	Aakerøy, Lars Nørstebø, Ester Alfer Thomas, Karen Marie Holte, Espen Hegbom, Knut Brønstad, Eivind Steinshamn, Sigurd
Copyright Year	2021
Abstract	ABSTRACTBackgroundExercise is recommended for all patients with COPD. Evidence for its benefit is considerably weaker in the more severe stages of the disease. The aim of this study was to investigate whether high-intensity interval training could improve exercise capacity, pulmonary hemodynamics and cardiac function in patients with severe COPD and hypoxemia.MethodsStable patients with COPD GOLD stage III or IV and hypoxemia were included. They underwent extensive cardiopulmonary testing including right heart catheterization, lung function tests, echocardiography and 6-minute walk test before and after completion of 10 weeks of high-intensity interval training performed with supplemental oxygen. Primary endpoint was change in pulmonary artery pressure measured by right heart catheterization.ResultsTen patients with very severe airflow obstruction, mean FEV1 28.7% predicted and mean FEV1/VC 0.39 completed the exercise programme. Pulmonary artery pressure remained unchanged following the intervention (26,3 mmHg vs. 25,8 mmHg at baseline, p 0.673). Six-minute walk distance improved by a mean of44.8 m (p 0.010), which is also clinically significant. We found marginally improved left ventricular ejection fraction on echocardiography (54.6% vs 59.5%, p 0.046).ConclusionHigh-intensity interval training significantly improved exercise capacity while pulmonary hemodynamics remained unchanged. The improvement may therefore be due to mechanisms other than altered pulmonary artery pressure. The increase in ejection fraction is of uncertain clinical significance. The low number of patients precludes firm conclusions.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8603835&blobtype=pdf
Page Count	1
Journal	European Clinical Respiratory Journal [Eur Clin Respir J]
Volume Number	8
DOI	10.1080/20018525.2021.1984642
PubMed Central reference number	PMC8603835
Issue Number	1
PubMed reference number	34804414
e-ISSN	20018525
Language	English
Publisher	Taylor & Francis
Publisher Date	2021-10-11
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Subject Keyword	Exercise rehabilitation interval training catheterization pulmonary hypertension
Content Type	Text
Resource Type	Article
Subject	Pulmonary and Respiratory Medicine