NDLI: STING mediates immune responses in the closest living relatives of animals.

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STING mediates immune responses in the closest living relatives of animals.

Content Provider	Europe PMC
Author	Woznica, Arielle Kumar, Ashwani Sturge, Carolyn R Xing, Chao King, Nicole Pfeiffer, Julie K
Editor	Cherry, Sara Taniguchi, Tadatsugu
Copyright Year	2021
Abstract	Animals have evolved unique repertoires of innate immune genes and pathways that provide their first line of defense against pathogens. To reconstruct the ancestry of animal innate immunity, we have developed the choanoflagellate Monosiga brevicollis, one of the closest living relatives of animals, as a model for studying mechanisms underlying pathogen recognition and immune response. We found that M. brevicollis is killed by exposure to Pseudomonas aeruginosa bacteria. Moreover, M. brevicollis expresses STING, which, in animals, activates innate immune pathways in response to cyclic dinucleotides during pathogen sensing. M. brevicollis STING increases the susceptibility of M. brevicollis to P. aeruginosa-induced cell death and is required for responding to the cyclic dinucleotide 2’3’ cGAMP. Furthermore, similar to animals, autophagic signaling in M. brevicollis is induced by 2’3’ cGAMP in a STING-dependent manner. This study provides evidence for a pre-animal role for STING in antibacterial immunity and establishes M. brevicollis as a model system for the study of immune responses.
Journal	eLife
Volume Number	10
PubMed Central reference number	PMC8592570
PubMed reference number	34730512
e-ISSN	2050084X
DOI	10.7554/elife.70436
Language	English
Publisher	eLife Sciences Publications, Ltd
Publisher Date	2021-11-03
Access Restriction	Open
Rights License	This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. © 2021, Woznica et al
Subject Keyword	choanoflagellates Monosiga brevicollis Pseudomonas aeruginosa STING
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Neuroscience Medicine Biochemistry, Genetics and Molecular Biology

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