NDLI: Nanocomposite Scaffolds for Monitoring of Drug Diffusion in Three-Dimensional Cell Environments by Surface-Enhanced Raman Spectroscopy.

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Nanocomposite Scaffolds for Monitoring of Drug Diffusion in Three-Dimensional Cell Environments by Surface-Enhanced Raman Spectroscopy.

Content Provider	Europe PMC
Author	Plou, Javier Molina-Martínez, Beatriz García-Astrain, Clara Langer, Judith García, Isabel Ercilla, Amaia Perumal, Govindaraj Carracedo, Arkaitz Liz-Marzán, Luis M.
Copyright Year	2021
Abstract	Monitoring dynamicprocesses in complex cellular environments requiresthe integration of uniformly distributed detectors within such three-dimensional(3D) networks, to an extent that the sensor could provide real-timeinformation on nearby perturbations in a non-invasive manner. In thiscontext, the development of 3D-printed structures that can functionas both sensors and cell culture platforms emerges as a promisingstrategy, not only for mimicking a specific cell niche but also towardidentifying its characteristic physicochemical conditions, such asconcentration gradients. We present herein a 3D cancer model thatincorporates a hydrogel-based scaffold containing gold nanorods. Inaddition to sustaining cell growth, the printed nanocomposite inksdisplay the ability to uncover drug diffusion profiles by surface-enhancedRaman scattering, with high spatiotemporal resolution. We additionallydemonstrate that the acquired information could pave the way to designingnovel strategies for drug discovery in cancer therapy, through correlationof drug diffusion with cell death.
ISSN	15306984
Journal	Nano Letters
Volume Number	21
PubMed Central reference number	PMC8554797
Issue Number	20
PubMed reference number	34614348
e-ISSN	15306992
DOI	10.1021/acs.nanolett.1c03070
Language	English
Publisher	American Chemical Society
Publisher Date	2021-10-06
Access Restriction	Open
Rights License	Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). © 2021 The Authors. Published by American Chemical Society
Subject Keyword	surface-enhanced Raman spectroscopy SERS nanocomposite scaffold 3D cell culture drugdiffusion
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Chemistry Condensed Matter Physics Bioengineering Materials Science Mechanical Engineering

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