Epigenetic dysregulation in various types of cells exposed to extremely low-frequency magnetic fields.

Content Provider	Europe PMC
Author	Giorgi, Gianfranco Del Re, Brunella
Abstract	Epigenetic mechanisms regulate gene expression, without changing the DNA sequence, and establish cell-type-specific temporal and spatial expression patterns. Alterations of epigenetic marks have been observed in several pathological conditions, including cancer and neurological disorders. Emerging evidence indicates that a variety of environmental factors may cause epigenetic alterations and eventually influence disease risks. Humans are increasingly exposed to extremely low-frequency magnetic fields (ELF-MFs), which in 2002 were classified as possible carcinogens by the International Agency for Research on Cancer. This review summarizes the current knowledge of the link between the exposure to ELF-MFs and epigenetic alterations in various cell types. In spite of the limited number of publications, available evidence indicates that ELF-MF exposure can be associated with epigenetic changes, including DNA methylation, modifications of histones and microRNA expression. Further research is needed to investigate the molecular mechanisms underlying the observed phenomena.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8526474&blobtype=pdf
ISSN	0302766X
Journal	Cell and Tissue Research [Cell Tissue Res]
Volume Number	386
DOI	10.1007/s00441-021-03489-6
PubMed Central reference number	PMC8526474
Issue Number	1
PubMed reference number	34287715
e-ISSN	14320878
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2021-07-21
Publisher Place	Berlin/Heidelberg
Access Restriction	Open
Rights License	Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2021
Subject Keyword	Epigenetics DNA methylation Histone modifications MicroRNA Electromagnetic magnetic field
Content Type	Text
Resource Type	Article
Subject	Cell Biology Histology Pathology and Forensic Medicine