Renal involvement in COVID-19: focus on kidney transplant sector.

Content Provider	Europe PMC
Author	Sagnelli, Caterina Sica, Antonello Gallo, Monica Peluso, Gaia Varlese, Filippo D’Alessandro, Vincenzo Ciccozzi, Massimo Crocetto, Felice Garofalo, Carlo Fiorelli, Alfonso Iannuzzo, Gabriella Reginelli, Alfonso Schonauer, Fabrizo Santangelo, Michele Sagnelli, Evangelista Creta, Massimiliano Calogero, Armando
Abstract	IntroductionKidney transplant recipients and patients on the waiting list for kidney transplant who acquire SARS-CoV-2 infection are at serious risk of developing severe COVID-19, with an increased risk of mortality for the their immunosuppressive state; other risk factors for mortality have been identified in some comorbidities such as obesity, diabetes, asthma and chronic lung disease.Materials and MethodsThe COVID-19 pandemic has led to a sharp reduction in kidney transplants in most countries, mainly due to the concern of patients on the waiting list for their potential increased susceptibility to acquire SARS-CoV-2 infection in healthcare facilities and for the difficulties of transplant centers to ensure full activity as hospitals have had to focus most of their attention on COVID-19 patients. Indeed, while the infection curve continued its exponential rise, there was a vertical decline in kidney donation/transplant activity.ConclusionThis review article focuses on the damage induced by SARS-CoV-2 infection on kidney and on the adverse effect of this pandemic on the entire kidney transplant sector.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8491762&blobtype=pdf
ISSN	03008126
Journal	Infection
Volume Number	49
DOI	10.1007/s15010-021-01706-6
PubMed Central reference number	PMC8491762
Issue Number	6
PubMed reference number	34611792
e-ISSN	14390973
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2021-10-05
Publisher Place	Berlin/Heidelberg
Access Restriction	Open
Rights License	This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. © Springer-Verlag GmbH Germany, part of Springer Nature 2021
Subject Keyword	Kidney transplantation Immunosuppressant COVID-19 SARS-CoV-2
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Microbiology (medical)