NDLI: Therapeutic Stalemate in Heart Failure With Preserved Ejection Fraction.

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Therapeutic Stalemate in Heart Failure With Preserved Ejection Fraction.

Content Provider	Europe PMC
Author	Samson, Rohan Le Jemtel, Thierry H.
Abstract	AbstractThe findings of randomized trials of neurohormonal modulation have been neutral in heart failure with preserved ejection fraction and consistently positive in heart failure with reduced ejection. Left ventricular remodeling promotes the development and progression of heart failure with preserved and reduced ejection fraction. However, different stimuli mediate left ventricular remodeling that is commonly concentric in heart failure with preserved ejection fraction and eccentric in heart failure with reduced ejection. The stimuli that promote concentric left ventricular remodeling may account for the neutral findings of neuhormonal modulation in heart failure with preserved ejection fraction. Low‐grade systemic inflammation‐induced microvascular endothelial dysfunction is currently the leading hypothesis behind the development and progression of heart failure with preserved ejection fraction. The hypothesis provided the rationale for several randomized controlled trials that have led to neutral findings. The trials and their limitations are reviewed.
Page Count	10
Journal	Journal of the American Heart Association
Volume Number	10
PubMed Central reference number	PMC8477887
Issue Number	12
PubMed reference number	34056916
e-ISSN	20479980
DOI	10.1161/jaha.121.021120
Language	English
Publisher	John Wiley and Sons Inc.
Publisher Date	2021-05-31
Publisher Place	Hoboken
Access Restriction	Open
Rights License	This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. © 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.
Subject Keyword	coronary microvascular dysfunction HFpEF left ventricular remodeling systemic inflammation Heart Failure Remodeling Hypertension
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine

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