NDLI: Novel Immunological and Therapeutic Insights in Guillain-Barré Syndrome and CIDP.

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Novel Immunological and Therapeutic Insights in Guillain-Barré Syndrome and CIDP.

Content Provider	Europe PMC
Author	Querol, Luis Lleixà, Cinta
Abstract	Inflammatory neuropathies are a heterogeneous group of rare diseases of the peripheral nervous system that include acute and chronic diseases, such as Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). The etiology and pathophysiological mechanisms of inflammatory neuropathies are only partly known, but are considered autoimmune disorders in which an aberrant immune response, including cellular and humoral components, is directed towards components of the peripheral nerve causing demyelination and axonal damage. Therapy of these disorders includes broad-spectrum immunomodulatory and immunosuppressive treatments, such as intravenous immunoglobulin, corticosteroids, or plasma exchange. However, a significant proportion of patients do not respond to any of these therapies, and treatment selection is not optimized according to disease pathophysiology. Therefore, research on disease pathophysiology aiming to reveal clinically and functionally relevant disease mechanisms and the development of new treatment approaches are needed to optimize disease outcomes in CIDP and GBS. This topical review describes immunological progress that may help guide therapeutic strategies in the future in these two disorders.Supplementary InformationThe online version contains supplementary material available at 10.1007/s13311-021-01117-3.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8455117&blobtype=pdf
ISSN	19337213
Journal	Neurotherapeutics
Volume Number	18
DOI	10.1007/s13311-021-01117-3
PubMed Central reference number	PMC8455117
Issue Number	4
PubMed reference number	34549385
e-ISSN	18787479
Language	English
Publisher	Springer International Publishing
Publisher Date	2021-09-21
Publisher Place	Gewerbestrasse 11, Cham, Ch 6330, Switzerland
Access Restriction	Open
Rights License	© The American Society for Experimental NeuroTherapeutics, Inc. 2021
Subject Keyword	Inflammatory neuropathies Guillain-Barré syndrome Chronic inflammatory demyelinating polyradiculoneuropathy Immunomodulatory treatments
Content Type	Text
Resource Type	Article
Subject	Neurology (clinical) Pharmacology Pharmacology (medical)

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