Succinate Dehydrogenase Complex Iron Sulfur Subunit B (SDHB) Immunohistochemistry in Pheochromocytoma, Head and Neck Paraganglioma, Thoraco-Abdomino-Pelvic Paragangliomas: Is It a Good Idea to Use in Routine Work?

Content Provider	Europe PMC
Author	Gul, Aylin Ege Keser, Sevinc Hallac Barisik, Nagehan Ozdemir Gurbuz, Yesim Saliha Sensu, Sibel Erdogan, Nusret
Abstract	Background:In this study, we aimed to detect Succinate Dehydrogenase Complex Iron Sulfur Subunit B (SDHB) frequency in paragangliomas and pheochromocytomas (PPGL) with immunohistochemistry; compare with Pheochromacytoma of the Adrenal Gland Scaled Score (PASS) classification and analyse the differences between pheochromocytoma (Pheo), head-neck paragangliomas (HNPGL) and thoraco-abdominal-pelvic paraganglioma (TAPPGL) sub-groups. Methods:A total 114 PPGL cases (73 HNPGL, 15 TAPPGL and 27 Pheo belonging to 112 cases) are included. Immunohistochemically, SDHB and Ki-67 are investigated and malignancy risks are determined by PASS classification. Results are assessed statistically with chi-square test and p <0,01 is considered significant.Results:SDHB mutations are observed in 20 of 114 (17.54 %) PPGL cases, 3 (11,12%) of which is Pheo, 12 (16,44) is HNPGL, and 5 (35,71%) is TAPPGL (P <0,02). While 15/82 (18,29%) cases with SDHB mutations do not have a malignancy potential according to PASS classification, 5/32 (15,63%) cases has (p=0,73). TAPPGL, HNPGL and Pheo sub-groups have a significant difference between SDHB expression (p <0,02), malignancy potential according to PASS classification (p <0,0001) and Ki-67 proliferation index (p <0,0001). Conclusion:To identify patients for molecular pathological examination, routine application of SDHB immunohistochemistry to PPGL tumors are suggested especially in HNPGLs.
ISSN	15137368
Volume Number	22
PubMed Central reference number	PMC8418866
Issue Number	6
PubMed reference number	34181326
Journal	Asian Pacific Journal of Cancer Prevention : APJCP [Asian Pac. J. Cancer Prev]
e-ISSN	2476762X
DOI	10.31557/APJCP.2021.22.6.1721
Language	English
Publisher	West Asia Organization for Cancer Prevention
Publisher Date	2021-06-01
Publisher Place	Iran
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Subject Keyword	Pheochromocytoma paraganglioma SDHB immunohistochemistry
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health Cancer Research Epidemiology Oncology