Assessment of subclinical atherosclerosis with ankle-brachial index in psoriatic arthritis: A case-control study.

Content Provider	Europe PMC
Author	BİLİM, Serhad İÇAĞASIOĞLU, Afitap AKBAL, Ayla KASAPOĞLU, Esen GÜRSEL, Sıdıka
Copyright Year	2021
Abstract	ObjectivesThis study aims to evaluate subclinical atherosclerosis using the Ankle-Brachial Index (ABI) in patients with psoriatic arthritis (PsA). Patients and methodsThis case-control study included 51 PsA patients (24 males, 27 females; median age 47; range, 41 to 52 years) recruited at our hospital’s outpatient clinics between October 2016 and January 2017 and 50 healthy controls (24 males, 26 females; median age: 48.5; range, 40.7 to 56 years). Anthropomorphic measurements and laboratory results were recorded. In patients, the 66 swollen/68 tender joints count, dactylitis score, Leeds Enthesitis Index, Health-related Quality of Life, the Psoriasis Area and Severity Index, and Dermatology Life Quality Index were evaluated. Ankylosing Spondylitis Quality of Life and Bath Ankylosing Spondylitis Disease Activity Index were applied to patients with axial disease. Then, Composite Psoriatic Disease Activity Index was determined. A Doppler probe and a standard blood pressure cuff were used to calculate the ABI values for each participant.ResultsPatients had lower right ABI (median, 1.05 vs. 1.1, p<0.01), lower left ABI (1.04 vs. 1.09, p<0.01) and lower overall ABI (1.03 vs. 1.09, p<0.01) compared with healthy subjects. Twelve (23.5%) patients had borderline ABI, but none of the controls (p<0.01). Patients with borderline ABI had a longer duration of psoriasis (25 vs. 15 years, p=0.03). The distribution of borderline ABI value was statistically significant between patients with axial disease and peripheral disease only (42.1% vs. 12.5%, p=0.02). Disease activity was found as an independent risk factor for borderline ABI in a binary logistic regression (odds ratio 6.306, 95% confidence interval 1.185 to 33.561, p=0.031).ConclusionLower ABI was found in PsA patients than healthy controls even in those matched with traditional cardiovascular risk factors. All participants with borderline ABI were in the patient group. Borderline ABI was associated with disease activity and disease duration.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8418778&blobtype=pdf
ISSN	21485046
Journal	Archives of Rheumatology [Arch Rheumatol]
Volume Number	36
PubMed Central reference number	PMC8418778
Issue Number	2
PubMed reference number	34527925
e-ISSN	26186500
DOI	10.46497/archrheumatol.2021.8083
Language	English
Publisher	Turkish League Against Rheumatism
Publisher Date	2021-01-14
Access Restriction	Open
Rights License	This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. Copyright © 2021, Turkish League Against Rheumatism
Subject Keyword	Ankle-Brachial Index atherosclerosis cardiovascular disease peripheral artery disease psoriatic arthritis spondyloarthropathy
Content Type	Text
Resource Type	Article
Subject	Rheumatology