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Metabolic outcomes and renal function after simultaneous kidney/pancreas transplantation compared with kidney transplantation alone for type 2 diabetes mellitus patients.
| Content Provider | Europe PMC |
|---|---|
| Author | Fu, Yingxin Cao, Yu Wang, Hui Zhao, Jie Wang, Zhen Mo, Chunbai Shi, Xiaofeng Feng, Gang Song, Wenli |
| Abstract | SummaryIn this study, we aimed to compare the metabolic outcomes, renal function, and survival outcomes of simultaneous pancreas and kidney transplantation (SPK) and kidney transplantation alone (KTA) among end‐stage kidney disease (ESKD) patients with type II diabetes mellitus (T2DM). Patients with ESKD and T2DM who underwent KTA (n = 85) or SPK (n = 71) in a transplant center were retrospectively reviewed. Metabolic profiles, renal function, and survival outcomes were assessed repeatedly at different follow‐up time points. Propensity score procedures were applied to enhance between‐group comparability. The levels of renal and metabolic outcomes between SPK and KTA over time were examined and analyzed using mixed‐model repeated‐measures approaches. The median follow‐up period was 1.8 years. Compared with KTA, SPK resulted in superior metabolic outcomes and renal function, with lower levels of glycated hemoglobin (HbA1c; P = 0.0055), fasting blood glucose (P < 0.001), triglyceride (P = 0.015), cholesterol (P = 0.0134), low‐density lipoprotein (P = 0.0161), and higher estimated glomerular filtration rate (eGFR; P < 0.001). SPK provided better metabolic outcomes and renal function. The survival outcomes of the recipients and grafts were comparable between the two groups. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8362174&blobtype=pdf |
| Page Count | 14 |
| ISSN | 09340874 |
| Journal | Transplant International [Transpl Int] |
| Volume Number | 34 |
| DOI | 10.1111/tri.13892 |
| PubMed Central reference number | PMC8362174 |
| Issue Number | 7 |
| PubMed reference number | 33896062 |
| e-ISSN | 14322277 |
| Language | English |
| Publisher | John Wiley and Sons Inc. |
| Publisher Date | 2021-05-21 |
| Publisher Place | Hoboken |
| Access Restriction | Open |
| Rights License | This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. © 2021 The Authors. Transplant International published by John Wiley & Sons Ltd on behalf of Steunstichting ESOT. |
| Subject Keyword | kidney transplantation alone metabolic outcomes renal graft function simultaneous pancreas and kidney transplantation type II diabetes mellitus |
| Content Type | Text |
| Resource Type | Article |
| Subject | Transplantation |
