Parotid Neurogenic Tumors: MPNST Sarcoma to Schwannoma-Review of Literature and Guidelines in Management.

Content Provider	Europe PMC
Author	Chandra, Srinivasa Rama Das, Shibani Wolf, Alejandro
Abstract	Objective To delineate a distinct clinical, pathological, cytoimmunohistochemical distinguishing features of extracranial parotid neurogenic tumors. Pleomorphic adenoma, the most common parotid neoplasm by itself can mimic a neurogenic tumor, i.e., schwannoma. We have reported such rare entity in earlier publications. This is a systematic review with a case discussion of the third only documented malignant peripheral nerve sheath tumor (MPNST) arising in the parotid in a noncontiguous fashion. We review the management, diagnostic immunohistochemistry of this low-grade sarcoma, which has not been documented thus far. Purpose Significant diagnostic and management pitfalls may occur even with fine-needle aspiration or biopsy, as they will not be ideal in diagnosis of parotid neurogenic neoplasms preoperatively. Ultrasound as well as magnetic resonance imaging may not offer a specific facial nerve course in association to the neoplastic lesion. Majority of the neurogenic tumors can be misdiagnosed and hence, improperly managed leading to facial nerve injury and tumor morbidity. Due to the lack of ideal diagnostic modality and morbidity of facial nerve injury, a thorough review of differential diagnosis inclusive of neurogenic tumors of the parotid is to be considered in indications of surgical approaches. We retrospectively review successful resection with preservation of facial nerve function in our parotid neurogenic tumors. Conclusion The objective of this paper is to review the guidelines and treatment planning of parotid neurogenic tumors.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8313617&blobtype=pdf
ISSN	09728279
Volume Number	20
DOI	10.1007/s12663-021-01523-2
PubMed Central reference number	PMC8313617
Issue Number	3
PubMed reference number	34408362
Journal	Journal of Maxillofacial & Oral Surgery [J Maxillofac Oral Surg]
e-ISSN	0974942X
Language	English
Publisher	Springer India
Publisher Date	2021-03-23
Publisher Place	New Delhi
Access Restriction	Open
Rights License	© The Association of Oral and Maxillofacial Surgeons of India 2021
Subject Keyword	Parotid neurogenic tumors Malignant peripheral nerve sheath tumor Sarcoma Schwannoma Facial nerve Fine-needle aspiration Guidelines Management Systematic review
Content Type	Text
Resource Type	Article
Subject	Otorhinolaryngology Oral Surgery Surgery