NDLI: Study of the Antimalarial Activity of the Leaf Extracts and Fractions of <i>Persea americana</i> and <i>Dacryodes edulis</i> and Their HPLC Analysis.

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Study of the Antimalarial Activity of the Leaf Extracts and Fractions of Persea americana and Dacryodes edulis and Their HPLC Analysis.

Content Provider	Europe PMC
Author	Uzor, Philip F. Onyishi, Chukwuebuka K. Omaliko, Adaeze P. Nworgu, Somtochukwu A. Ugwu, Onyemaechi H. Nwodo, Ngozi J.
Copyright Year	2021
Abstract	In the present study, the antimalarial activity of the extracts and fractions of the leaves of Persea americana and Dacryodes edulis as well as their phytochemical compositions were examined. Each of the extracts of the plants was successively fractionated to obtain hexane, ethyl acetate, methanol, and water fractions. The extracts and fractions were tested against Plasmodium berghei in both curative and suppressive antimalarial mouse models. Their major phytochemical composition was studied by the standard chemical tests and HPLC analysis. The extracts and fractions of P. americana and D. edulis demonstrated significant (p < 0.05) maximal plasmodial inhibition as 52.16 ± 2.77% and 57.10 ± 1.98%, respectively, and chemosuppression of parasitemia as 64.01 ± 0.08% and 71.99 ± 0.06%, respectively. The major secondary metabolites identified in the plants include alkaloids, flavonoids, and saponins. It was concluded that P. americana and D. edulis possess promising antimalarial activity and they are potential sources of new lead compounds against malaria.
ISSN	1741427X
Journal	Evidence-based Complementary and Alternative Medicine : Ecam
Volume Number	2021
PubMed Central reference number	PMC8313334
PubMed reference number	34335810
e-ISSN	17414288
DOI	10.1155/2021/5218294
Language	English
Publisher	Hindawi
Publisher Date	2021-07-17
Access Restriction	Open
Rights License	This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2021 Philip F. Uzor et al.
Content Type	Text
Resource Type	Article
Subject	Complementary and Alternative Medicine

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