NDLI: Comprehensive overview of human serum albumin glycation in diabetes mellitus.

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Comprehensive overview of human serum albumin glycation in diabetes mellitus.

Content Provider	Europe PMC
Author	Qiu, Hong-Yan Hou, Ning-Ning Shi, Jun-Feng Liu, Yong-Ping Kan, Cheng-Xia Han, Fang Sun, Xiao-Dong
Copyright Year	2021
Abstract	The presence of excess glucose in blood is regarded as a sweet hurt for patients with diabetes. Human serum albumin (HSA) is the most abundant protein in human plasma, which undergoes severe non-enzymatic glycation with glucose in patients with diabetes; this modifies the structure and function of HSA. Furthermore, the advanced glycation end products produced by glycated HSA can cause pathological damage to the human body through various signaling pathways, eventually leading to complications of diabetes. Many potential glycation sites on HSA have different degrees of sensitivity to glucose concentration. This review provides a comprehensive assessment of the in vivo glycation sites of HSA; it also discusses the effects of glycation on the structure and function of HSA. Moreover, it addresses the relationship between HSA glycation and diabetes complications. Finally, it focuses on the value of non-enzymatic glycation of HSA in diabetes-related clinical applications.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8311477&blobtype=pdf
Journal	World Journal of Diabetes [World J Diabetes]
Volume Number	12
DOI	10.4239/wjd.v12.i7.1057
PubMed Central reference number	PMC8311477
Issue Number	7
PubMed reference number	34326954
e-ISSN	19489358
Language	English
Publisher	Baishideng Publishing Group Inc
Publisher Date	2021-07-01
Access Restriction	Open
Rights License	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Subject Keyword	Diabetes mellitus Human serum albumin Non-enzymatic glycation Advanced glycation end products Glycation sites Diabetic complications
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism

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