Association between ALDH2 and ADH1B Polymorphisms and the Risk for Colorectal Cancer in Koreans.

Content Provider	Europe PMC
Author	Choi, Chang Kyun Shin, Min-Ho Cho, Sang-Hee Kim, Hye-Yeon Zheng, Wei Long, Jirong Kweon, Sun-Seog
Copyright Year	2021
Abstract	PurposeExcessive alcohol consumption has been linked to an increased risk of colorectal cancer (CRC). We evaluated the association between alcohol-related genetic variants and CRC risk.Materials and MethodsThe study cohort consisted of 5,435 CRC cases and 3,553 population-based cancer-free controls. Genotype data were generated from germline DNA using the Infinium OncoArray-500K BeadChip in 2,535 cases and 2,287 controls and the Infinium Multi-Ethnic Global BeadChip in 2,900 cases and 1,266 controls. The associations between aldehyde dehydrogenase 2 (ALDH2) rs671 and alcohol dehydrogenase 1B (ADH1B) rs1229984 polymorphisms and CRC risk were assessed using multivariate logistic regression analyses.ResultsCompared with the major homozygous ALDH2 genotype (GG), heterozygous or minor homozygous ALDH2 genotype (GA or AA, related to a low alcohol consumption) was significantly associated with a reduced risk for CRC in men (odds ratio [OR], 0.78; 95% confidence interval [CI], 0.68 to 0.90), but not in women (OR, 0.70; 95% CI, 0.47 to 1.05). A stronger association was found among regular drinkers (OR, 0.58; 95% CI, 0.47 to 0.71 in men and OR, 0.33; 95% CI, 0.18 to 0.58 in women). No association of CRC risk with ADH1B rs1229984 genotype was found. The association between alcohol-related combined genotypes and risk of CRC was significant (p for linear=0.001). The combined genotype with the highest genetically predicted alcohol consumption (ALDH2 rs671 GG and ADH1B rs1229984 AG/GG) was associated with a high risk for CRC (OR, 1.35; 95% CI, 1.11 to 1.63).ConclusionOur study provides strong evidence for a possible causal association between alcohol consumption and CRC risk.
ISSN	15982998
Journal	Cancer Research and Treatment : Official Journal of Korean Cancer Association
Volume Number	53
PubMed Central reference number	PMC8291179
Issue Number	3
PubMed reference number	33421985
e-ISSN	20059256
DOI	10.4143/crt.2020.478
Language	English
Publisher	Korean Cancer Association
Publisher Date	2020-12-24
Access Restriction	Open
Rights License	This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2021 by the Korean Cancer Association
Subject Keyword	Alcohol Alcohol dehydrogenase 2 Aldehyde dehydrogenase 2 Colorectal neoplasm
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology