The Eyes Absent proteins in development and in developmental disorders.

Content Provider	Europe PMC
Author	Soni, Upendra Kumar Roychoudhury, Kaushik Hegde, Rashmi S.
Copyright Year	2021
Abstract	The Eyes Absent (EYA) transactivator-phosphatase proteins are important contributors to cell-fate determination processes and to the development of multiple organs. The transcriptional regulatory activity as well as the protein tyrosine phosphatase activities of the EYA proteins can independently contribute to proliferation, differentiation, morphogenesis and tissue homeostasis in different contexts. Aberrant EYA levels or activity are associated with numerous syndromic and non-syndromic developmental disorders, as well as cancers. Commensurate with the multiplicity of biochemical activities carried out by the EYA proteins, they impact upon a range of cellular signaling pathways. Here, we provide a broad overview of the roles played by EYA proteins in development, and highlight the molecular signaling pathways known to be linked with EYA-associated organ development and developmental disorders.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8286820&blobtype=pdf
ISSN	03005127
Journal	Biochemical Society Transactions [Biochem Soc Trans]
Volume Number	49
PubMed Central reference number	PMC8286820
Issue Number	3
PubMed reference number	34196366
e-ISSN	14708752
DOI	10.1042/bst20201302
Language	English
Publisher	Portland Press Ltd.
Publisher Date	2021-06-01
Access Restriction	Open
Rights License	This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND). © 2021 The Author(s)
Subject Keyword	branchio-oto-renal syndrome Eyes Absent organ development protein tyrosine phosphatase retinal determination gene network
Content Type	Text
Resource Type	Article
Subject	Biochemistry