Clinicopathological Features and Survival of Signet-Ring Cell Carcinoma and Mucinous Adenocarcinoma of Right Colon, Left Colon, and Rectum.

Content Provider	Europe PMC
Author	Zhu, Lili Ling, Chunrun Xu, Tao Zhang, Jinglin Zhang, Yujie Liu, Yingjie Fang, Chao Yang, Lie Zhuang, Wen Wang, Rui Ping, Jie Wang, Mojin
Copyright Year	2021
Abstract	Histological subtype plays an important role in the different clinical characteristics and survival outcomes of patients with colorectal carcinoma (CRC). However, in previous studies, the influences of tumor locations and tumor stages have not been strictly controlled. This study focused on the assessment of the prognostic value of each histological subtype in different tumor locations and tumor stages of CRC. We used the Surveillance, Epidemiology, and End Results (SEER) database (1973–2011) to analyze 818,229 CRC patients with different clinical and pathological features, and analyzed the prognostic value of each histological subtype. Under the condition of stratification by tumor stage, signet-ring cell carcinoma (SRCC) presented the worst survival in each stage of right colon cancer (stage I, log-rank, p = 0.002, stages II, III, and IV, log-rank, p < 0.001), rectal cancer (RC) (log-rank, p < 0.001), and in stages II, III, and IV of left colon cancer (log-rank, p < 0.001). Multivariate survival analysis suggested SRCC subtype, male gender, age ≥ 70 years, tumor size ≥ 5 cm, stage progression, and poor differentiation were all significant factors worsening survival in CRC (p < 0.001, respectively). Mucinous adenocarcinoma (MC) histological subtype proved to be an independent protective factor for the prognosis of right colon cancer (p = 0.003). Overall, in our study, the results suggested SRCC had the worst survival among the three histological subtypes of CRC. MC was associated with favorable prognosis in right colon cancer but not with other tumor locations.
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ISSN	12194956
Journal	Pathology and Oncology Research [Pathol Oncol Res]
Volume Number	27
DOI	10.3389/pore.2021.1609800
PubMed Central reference number	PMC8283508
PubMed reference number	34276258
e-ISSN	15322807
Language	English
Publisher	Frontiers Media S.A.
Publisher Date	2021-07-02
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Copyright © 2021 Zhu, Ling, Xu, Zhang, Zhang, Liu, Fang, Yang, Zhuang, Wang, Ping and Wang.
Subject Keyword	survival colorectal carcinoma signet-ring cell carcinoma histological subtype SEER
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology