NDLI: Higher admission activated partial thromboplastin time, neutrophil-lymphocyte ratio, serum sodium, and anticoagulant use predict in-hospital COVID-19 mortality in people with Diabetes: Findings from Two University Hospitals in the U.K.

Please wait, while we are loading the content...

Higher admission activated partial thromboplastin time, neutrophil-lymphocyte ratio, serum sodium, and anticoagulant use predict in-hospital COVID-19 mortality in people with Diabetes: Findings from Two University Hospitals in the U.K.

Content Provider	Europe PMC
Author	Iqbal, Ahmed Greig, Marni Arshad, Muhammad Fahad Julian, Thomas H. Ee Tan, Sher Elliott, Jackie
Copyright Year	2021
Abstract	AimsTo create and compare survival models from admission laboratory indices in people hospitalized with coronavirus disease 2019 (COVID-19) with and without diabetes.MethodsRetrospective observational study of patients with COVID-19 with or without diabetes admitted to Sheffield Teaching Hospitals from 29 February to 01 May 2020. Predictive variables for in-hospital mortality from COVID-19 were explored using Cox proportional hazard models.ResultsOut of 505 patients, 156 (30.8%) had diabetes mellitus (DM) of which 143 (91.7%) had type 2 diabetes. There were significantly higher in-hospital COVID-19 deaths in those with DM [DM COVID-19 deaths 54 (34.6%) vs. non-DM COVID-19 deaths 88 (25.2%): P < 0.05]. Activated partial thromboplastin time (APPT) > 24 s without anticoagulants (HR 6.38, 95% CI: 1.07–37.87: P = 0.04), APTT > 24 s with anticoagulants (HR 24.01, 95% CI: 3.63–159.01: P < 0.001), neutrophil–lymphocyte ratio > 8 (HR 6.18, 95% CI: 2.36–16.16: P < 0.001), and sodium > 136 mmol/L (HR 3.27, 95% CI: 1.12–9.56: P = 0.03) at admission, were only associated with in-hospital COVID-19 mortality for those with diabetes.ConclusionsAt admission, elevated APTT with or without anticoagulants, neutrophil–lymphocyte ratio and serum sodium are unique factors that predict in-hospital COVID-19 mortality in patients with diabetes compared to those without. This novel finding may lead to research into haematological and biochemical mechanisms to understand why those with diabetes are more susceptible to poor outcomes when infected with Covid-19, and contribute to identification of those most at risk when admitted to hospital.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8278840&blobtype=pdf
ISSN	01688227
Journal	Diabetes Research and Clinical Practice [Diabetes Res Clin Pract]
Volume Number	178
DOI	10.1016/j.diabres.2021.108955
PubMed Central reference number	PMC8278840
PubMed reference number	34273452
e-ISSN	18728227
Language	English
Publisher	Elsevier B.V.
Publisher Date	2021-07-14
Access Restriction	Open
Rights License	Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. © 2021 Elsevier B.V. All rights reserved.
Subject Keyword	COVID-19 Mortality Diabetes mellitus Anticoagulants Activated partial thromboplastin time (APTT) Neutrophil-lymphocyte ratio
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Neutrophil-to-lymphocyte ratio on admission to predict the severity and mortality of COVID-19 patients: A meta-analysis.

The Neutrophil-to-Monocyte Ratio and Lymphocyte-to-Neutrophil Ratio at Admission Predict In-Hospital Mortality in Mexican Patients with Severe SARS-CoV-2 Infection (Covid-19)

Isolated Prolongation of Activated Partial Thromboplastin Time: Not Just Bleeding Risk!

Neutrophil-to-lymphocyte ratio on admission to predict the severity and mortality of COVID-19 patients: a meta-analysis

Hematological findings in COVID-19 and their correlation with severity of Disease.

Correlation between Serum Vitamin D3 Levels and Severity of COVID-19, Experience from a COVID-19-Dedicated Tertiary Care Hospital from Western India.

EFFECT OF DIABETES MELLITUS TYPE II ON ACTIVATED PARTIAL THROMBOPLASTIN TIME AND PROTHROMBIN TIME

Activated partial thromboplastin time (APTT)

Citrate Activated Partial Thromboplastin Time Citrat-aktivierte partielle Thromboplastinzeit ( APTT ) Citrate Activated Partial Thromboplastin

Higher admission activated partial thromboplastin time, neutrophil-lymphocyte ratio, serum sodium, and anticoagulant use predict in-hospital COVID-19 mortality in people with Diabetes: Findings from Two University Hospitals in the U.K.

Similar Documents

Neutrophil-to-lymphocyte ratio on admission to predict the severity and mortality of COVID-19 patients: A meta-analysis.

The Neutrophil-to-Monocyte Ratio and Lymphocyte-to-Neutrophil Ratio at Admission Predict In-Hospital Mortality in Mexican Patients with Severe SARS-CoV-2 Infection (Covid-19)

Isolated Prolongation of Activated Partial Thromboplastin Time: Not Just Bleeding Risk!

Neutrophil-to-lymphocyte ratio on admission to predict the severity and mortality of COVID-19 patients: a meta-analysis

Hematological findings in COVID-19 and their correlation with severity of Disease.

Correlation between Serum Vitamin D3 Levels and Severity of COVID-19, Experience from a COVID-19-Dedicated Tertiary Care Hospital from Western India.

EFFECT OF DIABETES MELLITUS TYPE II ON ACTIVATED PARTIAL THROMBOPLASTIN TIME AND PROTHROMBIN TIME

Activated partial thromboplastin time (APTT)

Citrate Activated Partial Thromboplastin Time Citrat-aktivierte partielle Thromboplastinzeit ( APTT ) Citrate Activated Partial Thromboplastin

Higher admission activated partial thromboplastin time, neutrophil-lymphocyte ratio, serum sodium, and anticoagulant use predict in-hospital COVID-19 mortality in people with Diabetes: Findings from Two University Hospitals in the U.K.