α-C(sp³)-H Arylation of Cyclic Carbonyl Compounds.

Content Provider	Europe PMC
Author	Wang, Mei Wang, Wei Li, Dashan Wang, Wen-Jing Zhan, Rui Shao, Li-Dong
Abstract	α-C(sp3)-H arylation is an important type of C-H functionalization. Various biologically significant natural products, chemical intermediates, and drugs have been effectively prepared via C-H functionalization. Cyclic carbonyl compounds comprise of cyclic ketones, enones, lactones, and lactams. The α-C(sp3)-H arylation of these compounds have been exhibited high efficiency in forming C(sp3)-C(sp2) bonds, played a crucial role in organic synthesis, and attracted majority of interests from organic and medicinal communities. This review focused on the most significant advances including methods, mechanism, and applications in total synthesis of natural products in the field of α-C(sp3)-H arylations of cyclic carbonyl compounds in recent years.
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ISSN	21922195
Journal	Natural Products and Bioprospecting [Nat Prod Bioprospect]
Volume Number	11
DOI	10.1007/s13659-021-00312-1
PubMed Central reference number	PMC8275813
Issue Number	4
PubMed reference number	34097248
e-ISSN	21922209
Language	English
Publisher	Springer Singapore
Publisher Date	2021-06-07
Publisher Place	Singapore
Access Restriction	Open
Rights License	Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2021
Subject Keyword	C-H functionalization α-C(sp3)-H arylation Cyclic carbonyl compounds
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Plant Science Analytical Chemistry Biochemistry Toxicology Pharmacology Food Science