Cerebral autoregulation assessed by near-infrared spectroscopy: validation using transcranial Doppler in patients with controlled hypertension, cognitive impairment and controls.

Content Provider	Europe PMC
Author	Mol, Arjen Meskers, Carel G. M. Sanders, Marit L. Müller, Martin Maier, Andrea B. van Wezel, Richard J. A. Claassen, Jurgen A. H. R. Elting, Jan Willem J.
Abstract	PurposeCerebral autoregulation (CA) aims to attenuate the effects of blood pressure variation on cerebral blood flow. This study assessed the criterion validity of CA derived from near-infrared spectroscopy (NIRS) as an alternative for Transcranial Doppler (TCD).MethodsMeasurements of continuous blood pressure (BP), oxygenated hemoglobin (O2Hb) using NIRS and cerebral blood flow velocity (CBFV) using TCD (gold standard) were performed in 82 controls, 27 patients with hypertension and 94 cognitively impaired patients during supine rest (all individuals) and repeated sit to stand transitions (cognitively impaired patients). The BP-CBFV and BP-O2Hb transfer function phase shifts (TFφ) were computed as CA measures. Spearman correlations (ρ) and Bland Altman limits of agreement (BAloa) between NIRS- and TCD-derived CA measures were computed. BAloa separation < 50° was considered a high absolute agreement.ResultsNIRS- and TCD-derived CA estimates were significantly correlated during supine rest (ρ = 0.22–0.30, N = 111–120) and repeated sit-to-stand transitions (ρ = 0.46–0.61, N = 19–32). BAloa separation ranged between 87° and 112° (supine rest) and 65°–77° (repeated sit to stand transitions).ConclusionCriterion validity of NIRS-derived CA measures allows for comparison between groups but was insufficient for clinical application in individuals.Supplementary InformationThe online version contains supplementary material available at 10.1007/s00421-021-04681-w.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8260523&blobtype=pdf
ISSN	14396319
Journal	European Journal of Applied Physiology [Eur J Appl Physiol]
Volume Number	121
DOI	10.1007/s00421-021-04681-w
PubMed Central reference number	PMC8260523
Issue Number	8
PubMed reference number	33860383
e-ISSN	14396327
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2021-04-16
Publisher Place	Berlin/Heidelberg
Access Restriction	Open
Rights License	Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2021
Subject Keyword	Cerebral autoregulation Near-infrared spectroscopy Transcranial Doppler Cognitive dysfunction Hypertension
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science