Value of Conventional MRI Texture Analysis in the Differential Diagnosis of Phyllodes Tumors and Fibroadenomas of the Breast.

Content Provider	Europe PMC
Author	Jiang, Nianping Zhong, Li Zhang, Chunlai Luo, Xiangguo Zhong, Peng Li, Xiaoguang
Copyright Year	2020
Abstract	Background There is substantial overlap in MRI findings between phyllodes tumors (PTs) and fibroadenomas (FAs). Our study was performed to investigate the value of conventional MRI texture analysis in the differential diagnosis of PTs and FAs. Methods Preoperative MRI data − including axial T1WI, T2WIFS (T2WI with fat suppression), dynamic contrast-enhanced (DCE)-T1WI2min and DCE-T1WI7min (T1WI post-strengthened for 2 and 7 min, respectively, on DCE-MRI) − of 45 patients with PTs and 67 patients with FAs were retrospectively analyzed. MaZda 4.7 software was used to manually draw the maximum ROIs at the same lesion level of the above MRI images. The optimized feature selection methods included Fisher's coefficient, probability of classification error and average correction coefficient (POE + ACC), and mutual information (MI) as well as a combination of the above 3 methods (F + POE + ACC + MI [FPM]), respectively. The misclassification rates of PTs and FAs were compared between texture analysis and subjective diagnosis by radiologists. Results The DCE-T1WI7min images had the lowest misclassification rate of 10.71% (12/112). The misclassification rate for the radiologists' analysis (31.25%, 35/112) was higher than that of all the texture analysis, and there was a statistically significant difference between the radiologists' misclassification rates and those from the FPM method in terms of the T2WIFS and DCE-T1WI2min images (all p < 0.05), and for the DCE-T1WI7min images by using the Fisher and FPM methods (all p < 0.05). Conclusion Texture analysis of conventional MRI can be used as an assistant tool in providing a certain objective basis for differentiating PTs from FAs.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8248772&blobtype=pdf
Page Count	8
ISSN	16613791
Volume Number	16
DOI	10.1159/000508456
PubMed Central reference number	PMC8248772
Issue Number	3
PubMed reference number	34248470
Journal	Breast Care [Breast Care (Basel)]
e-ISSN	16613805
Language	English
Publisher	Karger Publishers
Publisher Date	2020-06-23
Publisher Place	Allschwilerstrasse 10, CH-4055 Basel, Switzerland
Access Restriction	Open
Rights License	Copyright © 2020 by S. Karger AG, Basel
Subject Keyword	MRI Texture analysis Breast Phyllodes tumor Fibroadenoma Differential diagnosis
Content Type	Text
Resource Type	Article
Subject	Surgery Oncology