NDLI: Relationship between allergic rhinitis and diamine oxidase activity: A preliminary report.

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Relationship between allergic rhinitis and diamine oxidase activity: A preliminary report.

Content Provider	Europe PMC
Author	Mayo-Yáñez, Miguel Díaz-Díaz, Andrea Vázquez-Barro, Juan C. Herranz González-Botas, Jesús Figueroa, Angélica Martín-Martín, Carlos S.
Copyright Year	2021
Abstract	Aim: To analyze the diamine oxidase (DAO), the main catabolic enzyme of histamine, degradation activity and its relation with symptoms of persistent allergic rhinitis. Methods: In this descriptive and analytical observational study, we collected DAO activity levels and the nasal peak inspiratory flow. Results: Enzymatic activity deficit in 108 patients was 46.3% (95% CI, 0.44 – 0.63), 33.33% in mild and 47.92% in moderate/severe rhinitis (p = 0.376). The nasal peak inspiratory flow in patients with a deficit in DAO activity was 76.30 ± 28.40 L/min compared to 93.62 ± 37.50 L/min in patients with normal enzymatic activity (p = 0.010). Conclusions: It seems that the lower the catabolic activity of DAO, the lower the nasal peak inspiratory flow observed. Although DAO activity levels could be a severity biomarker in allergic rhinitis, a cause-effect association cannot be concluded. The enzyme could be another actor in the pathophysiology of allergic rhinitis.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8240126&blobtype=pdf
Volume Number	5
PubMed Central reference number	PMC8240126
PubMed reference number	34235375
Journal	Allergologie Select [Allergol Select]
e-ISSN	25128957
DOI	10.5414/als400537
Language	English
Publisher	Dustri-Verlag Dr. Karl Feistle
Publisher Date	2021-06-18
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. © Dustri-Verlag Dr. K. Feistle
Subject Keyword	allergic rhinitis diamine oxidase histamine intolerance nasal obstruction histamine
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy

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