NDLI: Catechol-O-methyltransferase (COMT) Val158Met Polymorphism and Susceptibility to Alcohol Dependence.

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Catechol-O-methyltransferase (COMT) Val158Met Polymorphism and Susceptibility to Alcohol Dependence.

Content Provider	Europe PMC
Author	Chaudhary, Amrita Kumar, Pradeep Rai, Vandana
Abstract	Catechol-O-methyl transferase (COMT) enzyme catalyzes the metabolism of dopamine and other catechols in the brain. Several articles investigated catechol-O-methyltransferase (COMT) Val158Met polymorphism as risk factor for alcohol dependence (AD) but the results were inconclusive. The aim of present meta-analysis was to evaluate the association of Val158Met (COMT) polymorphism with AD. Authors performed keyword search of the 4 electronic databases—Pubmed, Google Scholar, Springer Link and Science Direct databases up to December 31, 2019. Total eighteen studies that investigated the association of Val158Met polymorphism with AD were retrieved. The pooled results from the meta-analysis (2278 AD cases and 3717 healthy controls) did not show association with AD using all 5 genetic models (allele contrast model: OR = 1.02, 95% CI = 0.90–1.14, p = 0.03; homozygote model: OR = 1.06, 95% CI = 0.81–1.38, p = 0.69; dominant model: OR = 0.99, 95% CI = 0.85–1.14, p = 0.87; co-dominant model: OR = 0.97, 95% CI = 0.86–1.11, p = 0.71; recessive model: OR = 1.05;95% CI = 0.85–1.29, p = 0.61). Results of subgroup analysis showed that Val158Met is not risk for AD in Asian and Caucasian population. In conclusion, COMT Val158Met is not a risk factor for alcohol dependence.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8215027&blobtype=pdf
ISSN	09701915
Volume Number	36
DOI	10.1007/s12291-020-00933-2
PubMed Central reference number	PMC8215027
Issue Number	3
PubMed reference number	34220001
Journal	Indian Journal of Clinical Biochemistry [Indian J Clin Biochem]
e-ISSN	09740422
Language	English
Publisher	Springer India
Publisher Date	2021-01-02
Publisher Place	New Delhi
Access Restriction	Open
Rights License	© Association of Clinical Biochemists of India 2021
Subject Keyword	Alcohol dependence AD COMT Val158Met Meta-analysis Polymorphism
Content Type	Text
Resource Type	Article
Subject	Clinical Biochemistry

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