Higher-order organization of biomolecular condensates.

Content Provider	Europe PMC
Author	Fare, Charlotte M. Villani, Alexis Drake, Lauren E. Shorter, James
Copyright Year	2021
Abstract	A guiding principle of biology is that biochemical reactions must be organized in space and time. One way this spatio-temporal organization is achieved is through liquid–liquid phase separation (LLPS), which generates biomolecular condensates. These condensates are dynamic and reactive, and often contain a complex mixture of proteins and nucleic acids. In this review, we discuss how underlying physical and chemical processes generate internal condensate architectures. We then outline the diverse condensate architectures that are observed in biological systems. Finally, we discuss how specific condensate organization is critical for specific biological functions.
Journal	Open Biology
Volume Number	11
PubMed Central reference number	PMC8205532
Issue Number	6
PubMed reference number	34129784
e-ISSN	20462441
DOI	10.1098/rsob.210137
Language	English
Publisher	The Royal Society
Publisher Date	2021-06-16
Access Restriction	Open
Rights License	Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. © 2021 The Authors.
Subject Keyword	biomolecular condensate membraneless organelle liquid–liquid phase separation
Content Type	Text
Resource Type	Article
Subject	Immunology Biochemistry, Genetics and Molecular Biology Neuroscience