Loading...
Please wait, while we are loading the content...
Similar Documents
Sprint interval training (SIT) reduces serum epidermal growth factor (EGF), but not other inflammatory cytokines in trained older men.
| Content Provider | Europe PMC |
|---|---|
| Author | Yasar, Zerbu Elliott, Bradley T. Kyriakidou, Yvoni Nwokoma, Chiazor T. Postlethwaite, Ruth D. Gaffney, Christopher J. Dewhurst, Susan Hayes, Lawrence D. |
| Abstract | PurposeThe present study aimed to investigate the effect of age on circulating pro- and anti-inflammatory cytokines and growth factors. A secondary aim was to investigate whether a novel sprint interval training (SIT) intervention (3 × 20 s ‘all out’ static sprints, twice a week for 8 weeks) would affect inflammatory markers in older men.MethodsNine older men [68 (1) years] and eleven younger men [28 (2) years] comprised the younger group. Aerobic fitness and inflammatory markers were taken at baseline for both groups and following the SIT intervention for the older group.ResultsInterleukin (IL)-8, vascular endothelial growth factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1) were unchanged for the older and younger groups at baseline (IL-8, p = 0.819; MCP-1, p = 0.248; VEGF, p = 0.264). Epidermal growth factor (EGF) was greater in the older group compared to the younger group at baseline [142 (20) pg mL−1 and 60 (12) pg mL−1, respectively, p = 0.001, Cohen's d = 1.64]. Following SIT, older men decreased EGF to 100 (12) pg mL−1 which was similar to that of young men who did not undergo training (p = 0.113, Cohen's d = 1.07).ConclusionOlder aerobically trained men have greater serum EGF than younger aerobically trained men. A novel SIT intervention in older men can shift circulating EGF towards trained younger concentrations. As lower EGF has previously been associated with longevity in C. elegans, the manipulative effect of SIT on EGF in healthy ageing in the human may be of further interest. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8192388&blobtype=pdf |
| ISSN | 14396319 |
| Journal | European Journal of Applied Physiology [Eur J Appl Physiol] |
| Volume Number | 121 |
| DOI | 10.1007/s00421-021-04635-2 |
| PubMed Central reference number | PMC8192388 |
| Issue Number | 7 |
| PubMed reference number | 33723630 |
| e-ISSN | 14396327 |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2021-03-16 |
| Publisher Place | Berlin/Heidelberg |
| Access Restriction | Open |
| Rights License | Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2021 |
| Subject Keyword | Ageing Cytokines Exercise Growth factors HIIT Inflammation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science |
