Presynaptic NMDA receptors facilitate short-term plasticity and BDNF release at hippocampal mossy fiber synapses.

Content Provider	Europe PMC
Author	Lituma, Pablo J Kwon, Hyung-Bae Alviña, Karina Luján, Rafael Castillo, Pablo E
Editor	Westbrook, Gary L Toth, Katalin
Copyright Year	2021
Abstract	Neurotransmitter release is a highly controlled process by which synapses can critically regulate information transfer within neural circuits. While presynaptic receptors – typically activated by neurotransmitters and modulated by neuromodulators – provide a powerful way of fine-tuning synaptic function, their contribution to activity-dependent changes in transmitter release remains poorly understood. Here, we report that presynaptic NMDA receptors (preNMDARs) at mossy fiber boutons in the rodent hippocampus can be activated by physiologically relevant patterns of activity and selectively enhance short-term synaptic plasticity at mossy fiber inputs onto CA3 pyramidal cells and mossy cells, but not onto inhibitory interneurons. Moreover, preNMDARs facilitate brain-derived neurotrophic factor release and contribute to presynaptic calcium rise. Taken together, our results indicate that by increasing presynaptic calcium, preNMDARs fine-tune mossy fiber neurotransmission and can control information transfer during dentate granule cell burst activity that normally occur in vivo.
Journal	eLife
Volume Number	10
PubMed Central reference number	PMC8186907
PubMed reference number	34061025
e-ISSN	2050084X
DOI	10.7554/elife.66612
Language	English
Publisher	eLife Sciences Publications, Ltd
Publisher Date	2021-06-01
Access Restriction	Open
Rights License	This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. © 2021, Lituma et al
Subject Keyword	CA3 ionotropic hippocampus presynaptic calcium autoreceptors Mouse Rat
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Neuroscience Medicine Biochemistry, Genetics and Molecular Biology