Correlation Between Choriocapillaris Density and Retinal Sensitivity in Age-Related Macular Degeneration.

Content Provider	Europe PMC
Author	Di Perna, Luigi Melillo, Paolo Gesualdo, Carlo Palmieri, Filomena Testa, Francesco Bifani, Mario Rossi, Settimio Simonelli, Francesca
Copyright Year	2021
Abstract	PurposeThe purpose of this study was to investigate the relationship between perfusion of the choriocapillaris (CC) and retinal sensitivity in eyes with intermediate age-related macular degeneration (iAMD).MethodsThis prospective study included patients with iAMD and healthy controls. All enrolled subjects underwent optical coherence tomography angiography (OCT-A) in order to compute the percent perfused choriocapillaris area (PPCA). In patients with iAMD, microperimetry (MP) testing was performed in order to quantify: mean retinal sensitivity (MRS), over an area of 10 degrees; mean macular sensitivity (MMS), over the macular area scanned with OCT-A; and retinal sensitivity (RS) in each macular point.ResultsEighteen eyes of 13 patients were included in the analysis. In addition, 18 eyes of 12 healthy subjects were enrolled as controls. No statistically significant difference (P value > 0.2) was observed in age between patients (73.9 ± 2.0 years) and controls (70.1 ± 2.8 years). We observed significantly lower values of PPCA between patients with iAMD and healthy controls (42.0% ± 3.8% vs. 66.4% ± 3.0%; -β = 23.8%; P value < 0.001). Among iAMD eyes, higher values of PPCA were significantly associated with higher values of MRS (P value = 0.002) and MMS (P value = 0.013). Finally, higher values of RS in each macular point analyzed with MP were significantly (P value < 0.001) associated with higher values of PPCA computed in circular regions of interest (ROIs) centered in each analyzed MP point with radii of 0.5 degrees and 1.0 degree.ConclusionsUsing OCT-A, we demonstrated a significant association between CC impairment and macular dysfunction, quantified by MP, in iAMD eyes.Translational RelevanceOCT-A could be a useful tool for detecting CC alterations and to monitor disease progression.
Page Count	9
Journal	Translational Vision Science & Technology
Volume Number	10
PubMed Central reference number	PMC8185398
Issue Number	7
PubMed reference number	34061948
e-ISSN	21642591
DOI	10.1167/tvst.10.7.2
Language	English
Publisher	The Association for Research in Vision and Ophthalmology
Publisher Date	2021-06-01
Access Restriction	Open
Rights License	This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. Copyright 2021 The Authors
Subject Keyword	age-related macular degeneration (AMD) optical coherence tomography angiography (OCT-A) microperimetry (MP) choriocapillaris (CC) mean macular sensitivity (MMS)
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering Ophthalmology