Reflectance Confocal Microscopy Identification of Subclinical Basal Cell Carcinoma after Vismodegib Treatment: Report of a Case.

Content Provider	Europe PMC
Author	Villani, Alessia Fabbrocini, Gabriella Costa, Claudia Scalvenzi, Massimiliano
Abstract	Although surgery represents the treatment of choice for the majority of basal cell carcinomas, different therapies are required to treat the advanced ones. Vismodegib and sonidegib are the two oral Smoothened (Smo) inhibitors approved for the treatment of advanced basal cell carcinoma. Clinical detection of subclinical basal cell carcinoma during and after vismodegib treatment could be difficult, requiring the use of dermoscopy and reflectance confocal microscopy as noninvasive diagnostic methods. We report the case of a 62-year-old woman with a locally advanced basal cell carcinoma successfully treated with vismodegib in which dermoscopy and reflectance confocal microscopy showed their superiority in detecting subclinical recurrent basal cell carcinoma developed on scar tissue after complete regression of the tumor.
ISSN	21938210
Journal	Dermatology and Therapy
Volume Number	11
PubMed Central reference number	PMC8163916
Issue Number	3
PubMed reference number	33856641
e-ISSN	21909172
DOI	10.1007/s13555-021-00533-9
Language	English
Publisher	Springer Healthcare
Publisher Date	2021-04-15
Publisher Place	Cheshire
Access Restriction	Open
Rights License	Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/. © The Author(s) 2021
Subject Keyword	Vismodegib Reflectance confocal microscopy Dermoscopy Basal cell carcinoma Nonmelanoma skin cancer
Content Type	Text
Resource Type	Article
Subject	Dermatology