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From Protein Building Blocks to Functional Materials.
| Content Provider | Europe PMC |
|---|---|
| Author | Shen, Yi Levin, Aviad Kamada, Ayaka Toprakcioglu, Zenon Rodriguez-Garcia, Marc Xu, Yufan Knowles, Tuomas P. J. |
| Copyright Year | 2021 |
| Abstract | Proteinsare the fundamental building blocks for high-performancematerials in nature. Such materials fulfill structural roles, as inthe case of silk and collagen, and can generate active structuresincluding the cytoskeleton. Attention is increasingly turning to thisversatile class of molecules for the synthesis of next-generationgreen functional materials for a range of applications. Protein nanofibrilsare a fundamental supramolecular unit from which many macroscopicprotein materials are formed. In this Review, we focus on the multiscaleassembly of such protein nanofibrils formed from naturally occurringproteins into new supramolecular architectures and discuss how theycan form the basis of material systems ranging from bulk gels, films,fibers, micro/nanogels, condensates, and active materials. We reviewcurrent and emerging approaches to process and assemble these buildingblocks in a manner which is different to their natural evolutionarilyselected role but allows the generation of tailored functionality,with a focus on microfluidic approaches. We finally discuss opportunitiesand challenges for this class of materials, including applicationsthat can be involved in this material system which consists of fullynatural, biocompatible, and biodegradable feedstocks yet has the potentialto generate materials with performance and versatility rivalling thatof the best synthetic polymers. |
| ISSN | 19360851 |
| Journal | ACS Nano |
| Volume Number | 15 |
| PubMed Central reference number | PMC8155333 |
| Issue Number | 4 |
| PubMed reference number | 33760579 |
| e-ISSN | 1936086X |
| DOI | 10.1021/acsnano.0c08510 |
| Language | English |
| Publisher | AmericanChemical Society |
| Publisher Date | 2021-03-24 |
| Access Restriction | Open |
| Rights License | Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). © 2021 American ChemicalSociety |
| Subject Keyword | protein biomaterial gel fiber film microfluidic self-assembly drug delivery condensate |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Physics and Astronomy Engineering Materials Science |
