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Mortality and clinical outcomes in patients with COVID-19 pneumonia treated with non-invasive respiratory support: A rapid review.
| Content Provider | Europe PMC |
|---|---|
| Author | Radovanovic, Dejan Coppola, Silvia Franceschi, Elisa Gervasoni, Fabrizio Duscio, Eleonora Chiumello, Davide Alberto Santus, Pierachille |
| Copyright Year | 2021 |
| Abstract | Introduction and aimNon-invasive ventilation (NIV) and continuous positive airway pressure (CPAP) have been widely employed to treat acute respiratory failure secondary to COVID-19 pneumonia, but their role in terms of efficacy and safety are still debated. The aim of this review was to analyse mortality and intubation rates in COVID-19 patients treated with NIV/CPAP.MethodsRapid review methodology was applied to include all the studies published since December-2019 until November-2020 with available data on in-hospital mortality in COVID-19 patients treated with NIV or CPAP.Results23 manuscripts were included (4776 patients, 66% males, 46% with hypertension). 46% of patients received non-invasive respiratory support, of which 48.4% with CPAP, 46% with NIV, and 4% with either CPAP or NIV. Non-invasive respiratory support failed in 47.7% of patients, of which 26.5% were intubated and 40.9% died. In-hospital mortality was higher in patients treated with NIV compared with CPAP (35.1% vs. 22.2%). Complications were under-reported, but mostly not related to CPAP/NIV treatment.ConclusionCPAP and NIV appear equally and frequently applied in patients with COVID-19 pneumonia, but associated with high mortality. Robust evidence is urgently needed to confirm the clinical efficacy of non-invasive respiratory support in COVID-19-related ARDS. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8137355&blobtype=pdf |
| ISSN | 08839441 |
| Journal | Journal of Critical Care [J Crit Care] |
| Volume Number | 65 |
| DOI | 10.1016/j.jcrc.2021.05.007 |
| PubMed Central reference number | PMC8137355 |
| PubMed reference number | 34052780 |
| e-ISSN | 15578615 |
| Language | English |
| Publisher | Elsevier Inc. |
| Publisher Date | 2021-05-21 |
| Access Restriction | Open |
| Rights License | Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. © 2021 Elsevier Inc. All rights reserved. |
| Subject Keyword | COVID-19 Respiratory failure Non-invasive ventilation Continuous positive airway pressure Intubation Mortality ARDS, Acute Respiratory Distress Syndrome CPAP, Continuous Positive Airway Pressure DNI, Do Not Intubate ETI, EndoTracheal Intubation ICU, Intensive Care Unit IMV, Invasive Mechanical Ventilation NIV, Non Invasive Ventilation WHO, World Health Organization |
| Content Type | Text |
| Resource Type | Article |
| Subject | Critical Care and Intensive Care Medicine |
