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A Case of Muir-Torre Syndrome.
| Content Provider | Europe PMC |
|---|---|
| Author | Sheth, Radhika Menon, Priya Malik, Devin |
| Editor | Muacevic, Alexander Adler, John R |
| Copyright Year | 2021 |
| Abstract | Muir-Torre syndrome (MTS) is an autosomal dominant condition characterized by dermatological tumors along with visceral malignancies. The dermatological manifestations include recurrent sebaceous adenomas and keratoacanthomas. The commonly seen visceral malignancies are colorectal, gynecological, and urological. It is a variant of hereditary non-polyposis colorectal carcinoma syndrome (HNPCC). The underlying genetic mechanism is germline mutations in the DNA mismatch repair (MMR) genes leading to microsatellite instability (MSI), conferring an increased risk of developing malignancies. This is a case of a 57-year-old male patient with a history of colon cancer diagnosed at age 32 and multiple sebaceous adenomas. The patient also has a strong family history of cancer. They were referred to oncology after the immunohistochemical staining of a sebaceous adenoma showed loss of expression for MSH2 and MSH6. Next-generation sequencing identified a mutation in the MSH2 gene. These patients require genetic testing, counseling, and close follow-up with regular screening for cancer. |
| Journal | Cureus |
| Volume Number | 13 |
| DOI | 10.7759/cureus.14582 |
| PubMed Central reference number | PMC8136295 |
| Issue Number | 4 |
| PubMed reference number | 34036002 |
| e-ISSN | 21688184 |
| Language | English |
| Publisher | Cureus |
| Publisher Date | 2021-04-20 |
| Publisher Place | Palo Alto (CA) |
| Access Restriction | Open |
| Subject Keyword | muir-torre syndrome hnpcc lynch syndrome mismatch repair genes colon cancer |
| Content Type | Text |
| Resource Type | Case study |
| Subject | Medicine |
