Prognostic impact of additional HPV diagnostics in 102 patients with p16-stratified advanced oropharyngeal squamous cell carcinoma.

Content Provider	Europe PMC
Author	Weiss, Bernhard G. Anczykowski, Mahalia Zoe Küffer, Stefan Spiegel, Jennifer L. Bertlich, Mattis Canis, Martin Ihler, Friedrich Kitz, Julia Jakob, Mark
Abstract	Purposep16 overexpression was considered as surrogate marker to identify human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCCs).Methods102 patients with advanced stage OPSCCs treated primarily by transoral lasermicrosurgery were included. Prognostic associations of p16- and HPV-status were analyzed separately and combined.ResultsIn contrast to p16, the HPV-status resulted in no significant survival discrepancies (5-year overall survival (OS) HPV-positive 64.9%, HPV-negative 78.7%). Combining both markers, p16-positive (p16-positive/HPV-positive, p16-positive/HPV-negative) and p16-negative/HPV-negative groups demonstrated comparable high survival (OS 78.1% vs. 85.6% vs. 73.6%). Lowest survival was observed for patients with p16-negative/HPV-positive OPSCCs (OS 40.8%).Never smoking patients with p16-positive OPSCCs demonstrated the highest survival, whereas within former/current smokers with p16-positive and p16-negative disease it was comparable low (OS 90.0% vs. 63.0% vs. 57.4%).Conclusionsp16- and HPV-status should not be considered as equivalent markers for a better prognosis. Furthermore, they should not generally predominate patient associated factors like smoking.Electronic supplementary materialThe online version of this article (10.1007/s00405-020-06262-7) contains supplementary material, which is available to authorized users.
ISSN	09374477
Journal	European Archives of Oto-Rhino-Laryngology
Volume Number	278
PubMed Central reference number	PMC8131341
Issue Number	6
PubMed reference number	32814982
e-ISSN	14344726
DOI	10.1007/s00405-020-06262-7
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2020-08-20
Publisher Place	Berlin/Heidelberg
Access Restriction	Open
Rights License	Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2020
Subject Keyword	Oropharyngeal squamous cell carcinoma Oropharyngeal cancer p16 Human papillomavirus (HPV) Prognosis Head and neck squamous cell carcinomas (HNSCC)
Content Type	Text
Resource Type	Article
Subject	Otorhinolaryngology